Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42
Joint Authors
Maiti, Panchanan
Dunbar, Gary L.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aggregation of amyloid beta protein (Aβ) and phosphorylated tau (p-Tau) plays critical roles in pathogenesis of Alzheimer’s disease (AD).
As an antiamyloid natural polyphenol, curcumin (Cur) has a potential role in prevention of neurodegeneration in AD.
However, due to limited absorption of the dietary Cur, the solid lipid Cur particles (SLCP) have been suggested as being more effective for AD therapy.
In the present study, we compared the role of dietary Cur and SLCP on oxidative stress, neuronal death, p-Tau level, and certain cell survival markers in vitro, after exposure to Aβ42.
Mouse neuroblastoma cells were exposed to Aβ42 for 24 h and incubated with or without dietary Cur and/or SLCP.
Reactive oxygen species (ROS), apoptotic cell death, p-Tau, and tau kinase (including GSK-3β and cell survival markers, such as total Akt, phosphorylated Akt, and PSD95 levels) were investigated.
SLCP showed greater permeability than dietary Cur in vitro, decreased ROS production, and prevented apoptotic death.
In addition, SLCP also inhibited p-Tau formation and significantly decreased GSK-3β levels.
Further, the cell survival markers, such as total Akt, p-Akt, and PSD95 levels, were more effectively maintained by SLCP than dietary Cur in Aβ42 exposed cells.
Therefore, SLCP may provide greater neuroprotection than dietary Cur in Alzheimer’s disease.
American Psychological Association (APA)
Maiti, Panchanan& Dunbar, Gary L.. 2017. Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42. International Journal of Alzheimer's Disease،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1157678
Modern Language Association (MLA)
Maiti, Panchanan& Dunbar, Gary L.. Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42. International Journal of Alzheimer's Disease No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1157678
American Medical Association (AMA)
Maiti, Panchanan& Dunbar, Gary L.. Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42. International Journal of Alzheimer's Disease. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1157678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157678