Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia
Joint Authors
Petersen, Jindong Ding
Waldorff, Frans Boch
Siersma, Volkert Dirk
Phung, Thien Kieu Thi
Bebe, Anna Carina Klara Magdalena
Waldemar, Gunhild
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Depression and dementia are commonly concurrent and are both associated with increased mortality among older people.
However, little is known about whether home-dwelling patients newly diagnosed with mild dementia coexisting with depressive symptoms have excess mortality.
We conducted a post hoc analysis based on data from the Danish Alzheimer’s Intervention Study of 330 individuals who were diagnosed with mild dementia within the past 12 months.
Thirty-four patients were identified with major depressive symptoms (MD-S) at baseline.
During the 3-year follow-up period, 56 patients died, and, among them, 12 were with MD-S at baseline.
Multivariable analysis adjusting for the potential confounders (age, sex, smoking status, alcohol consumption, education, BMI, household status, MMSE, CCI, QoL-AD, NPIQ, ADSC-ADL, medication, and RCT allocation) showed that patients with MD-S had a 2.5-fold higher mortality as compared to the patients without or with only few depressive symptoms.
Our result revealed that depression is possibly associated with increased mortality in patients with mild dementia.
Given that depression is treatable, screening for depression and treatment of depression can be important already in the earliest stage of dementia to reduce mortality.
American Psychological Association (APA)
Petersen, Jindong Ding& Waldorff, Frans Boch& Siersma, Volkert Dirk& Phung, Thien Kieu Thi& Bebe, Anna Carina Klara Magdalena& Waldemar, Gunhild. 2017. Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia. International Journal of Alzheimer's Disease،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1157684
Modern Language Association (MLA)
Petersen, Jindong Ding…[et al.]. Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia. International Journal of Alzheimer's Disease No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1157684
American Medical Association (AMA)
Petersen, Jindong Ding& Waldorff, Frans Boch& Siersma, Volkert Dirk& Phung, Thien Kieu Thi& Bebe, Anna Carina Klara Magdalena& Waldemar, Gunhild. Major Depressive Symptoms Increase 3-Year Mortality Rate in Patients with Mild Dementia. International Journal of Alzheimer's Disease. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1157684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157684