Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor ProteinPresenilin 2 Mouse Model of Alzheimer’s Disease
Joint Authors
Kishimoto, Yasushi
Fukumoto, Kai
Nagai, Mika
Mizuguchi, Ayaka
Kobashi, Yuiko
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Presenilin 1 and presenilin 2 (PS1 and PS2) play a critical role in γ-secretase-mediated cleavage of amyloid-β precursor protein (APP) and the subsequent generation of β-amyloid peptides.
The purpose of the present study was to test whether PS2 mutation accelerates the onset of contextual fear memory deficits in a mouse model of AD that expresses a mutation (K670N/M671L) of the human APP with the Swedish mutation (Tg2576 mice).
In the present study, an APP/PS2 double-transgenic mouse model (PS2Tg2576) was generated by crossbreeding transgenic mice carrying the human mutant PS2 (N141I) with Tg2576 mice.
Contextual fear conditioning was tested in PS2Tg2576 mice aged 3, 4, 6, and 10–12 months.
PS2Tg2576 mice showed a tendency of lower freezing behavior as early as 3 months of age, but significant memory impairment was observed from the age of 4 months.
The cognitive impairment was more prominent at ages of 6 and 10–12 months.
In contrast, Tg2576 mice aged 3 and 4 months exhibited successful acquisition of contextual fear learning, but Tg2576 mice aged 6 months or older showed significantly impaired fear memory.
These results show that PS2 mutation significantly accelerates the onset of fear memory deficits in the APP AD model mice.
American Psychological Association (APA)
Kishimoto, Yasushi& Fukumoto, Kai& Nagai, Mika& Mizuguchi, Ayaka& Kobashi, Yuiko. 2017. Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor ProteinPresenilin 2 Mouse Model of Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1157687
Modern Language Association (MLA)
Kishimoto, Yasushi…[et al.]. Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor ProteinPresenilin 2 Mouse Model of Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1157687
American Medical Association (AMA)
Kishimoto, Yasushi& Fukumoto, Kai& Nagai, Mika& Mizuguchi, Ayaka& Kobashi, Yuiko. Early Contextual Fear Memory Deficits in a Double-Transgenic Amyloid-β Precursor ProteinPresenilin 2 Mouse Model of Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1157687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157687