Prediction of the Network Pharmacology-Based Mechanism for Attenuation of Atherosclerosis in Apolipoprotein E Knockout Mice by Panax notoginseng Saponins
Joint Authors
Zhou, Xue-Zhong
Fu, Changgeng
Long, Linzi
Yu, Zikai
Qu, Hua
Wang, Ning
Guo, Ming
Gao, Zhu-ye
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study investigated whether Panax notoginseng saponins (PNS) reduced atherosclerotic lesion formation in apolipoprotein E knockout (ApoE-KO) mice and illustrated the potential mechanism for a network pharmacology approach.
Pharmacodynamics studies on ApoE-KO mice with atherosclerosis (AS) showed that PNS generated an obvious anti-AS action.
Then, we explored the possible mechanisms underlying its anti-AS effect using the network pharmacology approach.
The main chemical components and their targets of PNS were collected from TCMSP public database and SymMap.
The STRING v11.0 was used to establish the protein-protein interactions of PNS.
Furthermore, the Gene Ontology (GO) function and KEGG pathways were analyzed using STRING to investigate the possible mechanisms involved in the anti-AS effect of PNS.
The predicted results showed that 27 potential targets regulated by DSLHG were related to AS, including ACTA2, AKT1, BCL2, and BDNF.
Mechanistically, the anti-AS effect of PNS was exerted by interfering with multiple signaling pathways, such as AGE-RAGE signaling pathway, fluid shear stress and atherosclerosis, and TNF signaling pathway.
Network analysis showed that PNS could generate the anti-AS action by affecting multiple targets and multiple pathways and provides a novel basis to clarify the mechanisms of anti-AS of PNS.
American Psychological Association (APA)
Long, Linzi& Yu, Zikai& Qu, Hua& Wang, Ning& Guo, Ming& Zhou, Xue-Zhong…[et al.]. 2020. Prediction of the Network Pharmacology-Based Mechanism for Attenuation of Atherosclerosis in Apolipoprotein E Knockout Mice by Panax notoginseng Saponins. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157724
Modern Language Association (MLA)
Long, Linzi…[et al.]. Prediction of the Network Pharmacology-Based Mechanism for Attenuation of Atherosclerosis in Apolipoprotein E Knockout Mice by Panax notoginseng Saponins. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1157724
American Medical Association (AMA)
Long, Linzi& Yu, Zikai& Qu, Hua& Wang, Ning& Guo, Ming& Zhou, Xue-Zhong…[et al.]. Prediction of the Network Pharmacology-Based Mechanism for Attenuation of Atherosclerosis in Apolipoprotein E Knockout Mice by Panax notoginseng Saponins. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1157724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157724