Kanglaite Injection Combined with Chemotherapy versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients with Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Jian
Wen, Jianxia
Ma, Xiao
Yang, Tao
Tong, Yuling
Zhao, Yanling
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-27
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Recent advances have shown that immune checkpoint inhibitors are emerging as promising therapeutic targets to improve the quality of life in cancer patients.
This meta-analysis was conducted to evaluate the influence of Kanglaite injection (KLTi) combined with chemotherapy versus chemotherapy alone on clinical efficacy, immune function, and safety for the treatment of advanced non-small-cell lung cancer (NSCLC).
Several electronic databases, including PubMed, Web of Science, Wan-Fang, VMIS, EMBASE, Cochrane Library, CNKI, CBM, and MEDLINE, as well as grey literatures, were comprehensively searched from January 2000 to November 2019.
Randomized controlled trials (RCTs) reporting outcomes of clinical efficacy and immune function were collected according to their inclusion and exclusion criteria.
Cochrane Reviewers’ Handbook 5.2 was applied to assess the risk of bias of included trials.
STATA 13.0 and Review Manager 5.3 software were used for meta-analysis.
Twenty-five RCTs comprising 2151 patients meeting the inclusion criteria were identified.
Meta-analysis showed that compared with chemotherapy alone, KLTi plus the same chemotherapy significantly improved clinical efficacy, including complete response, partial response, stable disease, and progressive disease, as well as immune function, including CD3+, CD4+, CD8+, and CD4+/CD8+.
There was a significant reduction in nausea and vomiting, thrombocytopenia, and leukopenia in combination treatments.
However, the outcomes were limited because of the low quality and small sample size of the included studies.
In conclusion, this work might provide beneficial evidence of KLTi combined with chemotherapy for improving clinical efficacy and immune function, as well as reducing the incidence of adverse events in advanced NSCLC patients.
KLTi might be a beneficial therapeutic method for the treatment of advanced NSCLC.
Due to the quality of the data, more rigorous and well-designed RCTs are needed to confirm these findings.
American Psychological Association (APA)
Wen, Jianxia& Yang, Tao& Wang, Jian& Ma, Xiao& Tong, Yuling& Zhao, Yanling. 2020. Kanglaite Injection Combined with Chemotherapy versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients with Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1157730
Modern Language Association (MLA)
Wen, Jianxia…[et al.]. Kanglaite Injection Combined with Chemotherapy versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients with Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1157730
American Medical Association (AMA)
Wen, Jianxia& Yang, Tao& Wang, Jian& Ma, Xiao& Tong, Yuling& Zhao, Yanling. Kanglaite Injection Combined with Chemotherapy versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients with Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1157730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157730