Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice
Joint Authors
Chen, Xuxi
Wu, Rui
Zhong, Shaoqi
Ni, Mengmei
Zhu, Xuejiao
Chen, Yiyi
Zhang, Lishi
Chen, Jinyao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
The fruits of Malania oleifera Chun & S.
K.
Lee have been highly sought after medically because its seeds have high oil content (>60%), especially the highest known proportion of nervonic acid (>55%).
Objective of the Study.
The objective was to explore the effects of different doses of Malania oleifera Chun oil (MOC oil) on the learning and memory of mice and to evaluate whether additional DHA algae oil and vitamin E could help MOC oil improve learning and memory and its possible mechanisms.
Methods.
After 30 days of oral administration of the relevant agents to mice, behavioral tests were conducted as well as detection of oxidative stress parameters (superoxide dismutase, malondialdehyde, and glutathione peroxidase) and biochemical indicators (acetylcholine, acetyl cholinesterase, and choline acetyltransferase) in the hippocampus.
Results.
Experimental results demonstrated that MOC oil treatment could markedly improve learning and memory of mouse models in behavioral experiments and increase the activity of GSH-PX in hippocampus and reduce the content of MDA, especially the dose of 46.27 mg/kg.
The addition of DHA and VE could better assist MOC oil to improve the learning and memory, and its mechanism may be related to the inhibition of oxidative stress and restrain the activity of AChE and also increase the content of ACh.
Conclusion.
Our results demonstrated that MOC oil treatment could improve learning and memory impairments.
Therefore, we suggest that MOC oil is a potentially important resource for the development of nervonic acid products.
American Psychological Association (APA)
Wu, Rui& Zhong, Shaoqi& Ni, Mengmei& Zhu, Xuejiao& Chen, Yiyi& Chen, Xuxi…[et al.]. 2020. Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157772
Modern Language Association (MLA)
Wu, Rui…[et al.]. Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1157772
American Medical Association (AMA)
Wu, Rui& Zhong, Shaoqi& Ni, Mengmei& Zhu, Xuejiao& Chen, Yiyi& Chen, Xuxi…[et al.]. Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1157772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157772