![](/images/graphics-bg.png)
In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice
Joint Authors
Forkuo, Arnold Donkor
Amponsah, Isaac Kingsley
Baah, Michael Kwesi
Mensah, Abraham Yeboah
Asante-Kwatia, Evelyn
Harley, Benjamin Kingsley
Adjei, Silas
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The emergence and resurgence of P.
falciparum resistance to generations of antimalarial drugs have prompted the search for new, effective, and safe antimalarial agents.
This study aimed at investigating the in vivo antiplasmodial activity of the 70% hydroethanolic extract and constituents of the stem bark of Myrianthus libericus based on its ethnomedicinal use as an antimalarial agent.
The antiplasmodial activity was assessed in Swiss albino mice employing the 4-day suppressive and Rane’s tests.
MLB significantly (p<0.0001) suppressed parasitaemia by 52.26%, 65.40%, and 77.11% at 50, 100, and 200 mg·kg−1 doses, respectively, in the 4-day suppressive test.
In Rane’s test, the highest parasitaemia suppression of 72.50% was recorded at a dose of 200 mg·kg−1 of the extract.
Fractionation of the bioactive ethyl acetate fraction by solvent-solvent partitioning and column chromatography led to the isolation of friedelan-3-one and stigmasterol being reported for the first time from this species.
The compounds demonstrated remarkable antiplasmodial activity by suppressing parasitaemia by 65–72% in the suppressive test and 61–70% in the curative test at doses of 10–30 mg·kg−1.
Both the extract and the isolated compounds significantly prolonged the survival time of infected mice and averted the cardinal signs associated with P.
berghei-induced malaria including weight loss, hypothermia, and haemolysis.
The results obtained confirm the prospect of M.
libericus as an important source of new antimalarial compounds and justifies its folkloric use as an antimalarial agent.
American Psychological Association (APA)
Baah, Michael Kwesi& Mensah, Abraham Yeboah& Asante-Kwatia, Evelyn& Amponsah, Isaac Kingsley& Forkuo, Arnold Donkor& Harley, Benjamin Kingsley…[et al.]. 2020. In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157862
Modern Language Association (MLA)
Baah, Michael Kwesi…[et al.]. In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157862
American Medical Association (AMA)
Baah, Michael Kwesi& Mensah, Abraham Yeboah& Asante-Kwatia, Evelyn& Amponsah, Isaac Kingsley& Forkuo, Arnold Donkor& Harley, Benjamin Kingsley…[et al.]. In Vivo Antiplasmodial Activity of Different Solvent Extracts of Myrianthus libericus Stem Bark and Its Constituents in Plasmodium berghei-Infected Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157862