Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta-Analysis
Joint Authors
Zhu, Hanfei
Ren, Ziqi
Zang, Yan
Hua, Hongxia
Lu, Jinling
Xu, Qin
Zhu, Shuqin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Vitamin deficiency, bacterial overgrowth, and gastrointestinal symptoms can be detected in obese patients after bariatric surgery that influences their quality of life (QoL) and weight.
It is unclear if microecological preparations benefit obese patients following bariatric surgery.
The aim of this study is to investigate the effects of microecological preparations on QoL, excess weight loss (EWL), and levels of vitamin B12 and inflammatory markers.
We searched seven databases to identify reports published till December 1, 2019, and included randomized controlled trials investigating the effects of microecological preparations in obese adults undergoing bariatric surgery.
The primary outcomes included QoL and EWL, while secondary outcomes comprised serum levels of vitamin B12, interleukin 6, TNF-α, and C-reactive protein (CRP).
Study bias was analyzed using the Cochrane risk-of-bias tool.
Statistical analyses were performed using Review Manager.
The mean difference in outcomes was calculated using standardized mean difference (SMD) with a confidence interval (CI) of 95%.
A majority of the studies showed a low or moderate risk of bias.
Meta-analysis showed significantly higher levels of vitamin B12 in postoperative patients administered with microecological preparations (SMD = 0.52; 95% CI = 0.08–0.95; P=0.02).
There were no significant differences in QoL (SMD = −0.14; 95% CI = −0.45–0.17; P=0.38), EWL (SMD = 0.45; 95% CI = −0.16–1.05; P=0.15), and levels of TNF-α (SMD = −0.29; 95% CI = −0.64–0.05; P=0.09), interleukin 6 (SMD = −0.1; 95% CI = −0.81–0.61; P=0.78]), and CRP (SMD = 0.02; 95% CI = −0.32–0.36; P=0.93).
The trials examined indicated that microecological preparations had limited efficacy in improving QoL, EWL, and inflammatory response, but they stimulated the synthesis of vitamin B12.
This may help in designing efficient microecological preparations to supplement bariatric surgery in obese individuals.
American Psychological Association (APA)
Zhu, Hanfei& Ren, Ziqi& Zang, Yan& Hua, Hongxia& Lu, Jinling& Xu, Qin…[et al.]. 2020. Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157875
Modern Language Association (MLA)
Zhu, Hanfei…[et al.]. Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1157875
American Medical Association (AMA)
Zhu, Hanfei& Ren, Ziqi& Zang, Yan& Hua, Hongxia& Lu, Jinling& Xu, Qin…[et al.]. Effects of Microecological Preparations on Obese Patients after Bariatric Surgery: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1157875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1157875