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Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products
Joint Authors
Sokpe, Authentia
Mensah, Merlin L. K.
Koffuor, George A.
Thomford, Kwesi P.
Arthur, Richmond
Jibira, Yakubu
Baah, Michael K.
Adedi, Bright
Agbemenyah, Hope Y.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Introduction.
In the management of hypertension (a cardiovascular disease and the leading metabolic risk factor in noncommunicable diseases) with herbal medicines, efficacy and safety are of uttermost concern.
This study sought to establish hypotensive, antihypertensive, drug interaction, and safety for use of the aqueous leaf extracts of Annona muricata (AME), Persea americana (PAE), or their combination products (CAPE).
Methodology.
Systolic and diastolic blood pressure (SBP and DBP), mean arterial blood pressure (MAP), and heart rate (HR) were measured in normotensive Sprague-Dawley rats treated with 50–150 mg/kg of AME, PAE, or CAPE to establish a hypotensive effect.
“Combination index” was calculated to establish interaction between AME and PAE.
The antihypertensive effect of CAPE was established by measuring SBP, DBP, MAP, and HR in ethanol-sucrose- and epinephrine-induced hypertension.
Full blood count, liver and kidney function tests, and urinalysis were determined in ethanol/sucrose-induced hypertension to establish safety for use.
Results.
AME, PAE, and CAPE significantly (p≤0.001) decreased BP in both normotensive and hypertensive animals.
Effects of CAPE 1, CAPE 2, and CAPE 3 were synergistic (combination indices of 0.65 ± 0.07, 0.76 ± 0.09, and 0.87 ± 0.07, respectively).
There was a significant decrease (p≤0.01−0.001) in SBP and MAP with 100 mg/kg CAPE 1 and 75 mg/kg CAPE 2 treatment in hypertension as well as with nifedipine (p≤0.001) treatment.
Epinephrine-induced hypertension in anesthetized cats was significantly and dose-dependently inhibited (p<0.05−0.001) by 25–100 mg/ml CAPE 1 and 37.5–75 mg/ml CAPE 2.
CAPE administration had no deleterious effect (p>0.05) on full blood count, liver and kidney function, and urine composition in hypertensive rats.
Conclusion.
The aqueous leaf extracts of Annona muricata, Persea americana, and their combination products possess antihypertensive properties, with combination products showing synergism and safety with use.
American Psychological Association (APA)
Sokpe, Authentia& Mensah, Merlin L. K.& Koffuor, George A.& Thomford, Kwesi P.& Arthur, Richmond& Jibira, Yakubu…[et al.]. 2020. Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1158030
Modern Language Association (MLA)
Sokpe, Authentia…[et al.]. Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1158030
American Medical Association (AMA)
Sokpe, Authentia& Mensah, Merlin L. K.& Koffuor, George A.& Thomford, Kwesi P.& Arthur, Richmond& Jibira, Yakubu…[et al.]. Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1158030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158030