Antihypertensive and Renal Protective Effects of Oryeongsan in Spontaneously Hypertensive Rats
Joint Authors
Kang, Kiwan
Jeong, Minjeong
Kim, Hongjun
Lim, Beomjin
Kim, Sangjun
Jang, Insoo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oryeongsan (ORS), a traditional medicine used to regulate body fluids, has a long history of use as a diuretic in Korea, China, and Japan.
ORS is commonly thought to lower blood pressure, but high-quality data on its effects are sparse.
The purpose of this study was to determine the antihypertensive and renal protective effects of ORS in rats with hypertension.
Spontaneously hypertensive rats (SHR) were divided into two groups with similar mean baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP).
Then, 10 mL/kg of vehicle (distilled water) or 200 mg/kg of ORS extract were administered orally once a day for 3 weeks.
SBP and DBP were measured at weeks 1, 2, and 3.
At the end of the experiment, blood was collected, and kidneys were removed for histology.
By the 2nd and 3rd week after initiation of treatment, the ORS-treated group had significantly lower SBP than control-treated rats (191.3 ± 6.5 vs.
206.3 ± 9.8 mmHg, p = 0.022 at the 2nd week; 195.8 ± 7.8 vs.
217.0 ± 8.1 mmHg, p = 0.003 at the 3rd week, respectively).
The ORS-treated group trended toward having a lower DBP than control, but there was no significant difference.
Blood urea nitrogen (BUN) and serum creatinine (Cr) were not different between the ORS-treated and control groups (BUN: 23.7 ± 1.1 vs.
22.7 ± 2.8 mg/dL, p = 0.508; Cr: 19.0 ± 2.2 vs.
21.6 ± 2.1 μM, p = 0.083, respectively).
The percentage of renal tissue affected by tubulointerstitial fibrosis was significantly lower in the ORS-treated group (1.68 ± 0.60) compared to controls (3.17 ± 0.96, p = 0.019).
These findings suggest that treatment with ORS reduces SBP and ameliorates renal damage in SHR.
American Psychological Association (APA)
Kang, Kiwan& Jeong, Minjeong& Kim, Hongjun& Lim, Beomjin& Kim, Sangjun& Jang, Insoo. 2020. Antihypertensive and Renal Protective Effects of Oryeongsan in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1158092
Modern Language Association (MLA)
Kang, Kiwan…[et al.]. Antihypertensive and Renal Protective Effects of Oryeongsan in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1158092
American Medical Association (AMA)
Kang, Kiwan& Jeong, Minjeong& Kim, Hongjun& Lim, Beomjin& Kim, Sangjun& Jang, Insoo. Antihypertensive and Renal Protective Effects of Oryeongsan in Spontaneously Hypertensive Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1158092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158092