Comparative Analysis of Clinical and Medication Information between Chronic Hepatitis B Patients with Damp Heat Syndrome and Spleen Deficiency Syndrome

Joint Authors

Liu, Qiao-Hong
Zhang, Bin-Bin
Xu, Lin
Shen, Xiao-Ping
Hai, Ya-Mei
Hu, Yi-Yang
Zhao, Yu

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-28

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Traditional Chinese medicine (TCM) has a long history in the treatment of chronic hepatitis B (CHB) based on the syndrome identification.

Previous studies reported CHB patients with damp-heat (DH) syndrome accompanied with a severe liver function damage, but lacked the medication analysis.

In this study, we analyzed 999 CHB patients with unidentified individual-level data from database to explore clinical features of two common syndromes of CHB patients based on the real world.

Compared with the spleen deficiency (SD) syndrome, the CHB patients with DH syndrome had a significantly higher level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (P<0.05) but took more immunomodulators and hepatoprotective drugs (P<0.1).

Similarly, in the follow-up of 207 patients after 3 months, the improvement trend of ALT and AST of patients with sustained SD syndrome was significantly better than those whose TCM syndrome changed from SD to DH (P<0.05).

The logistic model indicated DH syndrome was a significant negative factor for reducing ALT level in CHB patients (OR = 4.854, P=0.032).

This study suggests that CHB patients with DH syndrome have potentially more serious and sustained liver damage than the SD syndrome, which provides a reference for the personalized management of CHB patients from the perspective of TCM syndromes.

American Psychological Association (APA)

Liu, Qiao-Hong& Zhang, Bin-Bin& Xu, Lin& Shen, Xiao-Ping& Hai, Ya-Mei& Hu, Yi-Yang…[et al.]. 2020. Comparative Analysis of Clinical and Medication Information between Chronic Hepatitis B Patients with Damp Heat Syndrome and Spleen Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158093

Modern Language Association (MLA)

Liu, Qiao-Hong…[et al.]. Comparative Analysis of Clinical and Medication Information between Chronic Hepatitis B Patients with Damp Heat Syndrome and Spleen Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1158093

American Medical Association (AMA)

Liu, Qiao-Hong& Zhang, Bin-Bin& Xu, Lin& Shen, Xiao-Ping& Hai, Ya-Mei& Hu, Yi-Yang…[et al.]. Comparative Analysis of Clinical and Medication Information between Chronic Hepatitis B Patients with Damp Heat Syndrome and Spleen Deficiency Syndrome. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1158093

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1158093