To Explore the Mechanism and Equivalent Molecular Group of Fuxin Mixture in Treating Heart Failure Based on Network Pharmacology
Joint Authors
Yu, Yi-ding
Xiu, Yi-ping
Li, Yang-fan
Xue, Yi-tao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Fuxin mixture (FXHJ) is a prescription for the treatment of heart failure.
It has been shown to be effective in clinical trials, but its active ingredients and mechanism of action are not completely clear, which limits its clinical application and international promotion.
In this study, we used network pharmacology to find, conclude, and summarize the mechanism of FXHJ in the treatment of heart failure.
From FXHJ, we found 39 active ingredients and 47 action targets.
Next, we constructed the action network and was conducted enrichment analysis.
The results showed that FXHJ mainly treated heart failure by regulating the MAPK signaling pathway, PI3KAkt signaling pathway, cAMP signaling pathway, TNF signaling pathway, toll-like receptor signaling pathway, VEGF signaling pathway, NF-kappa B signaling pathway, and the apoptotic signaling molecule BCL2.
Through the research method of network pharmacology, this study summarized the preliminary experiments of the research group and revealed the probable mechanism of FXHJ in the treatment of heart failure to a certain extent, which provided some ideas for the development of new drugs.
American Psychological Association (APA)
Yu, Yi-ding& Xiu, Yi-ping& Li, Yang-fan& Xue, Yi-tao. 2020. To Explore the Mechanism and Equivalent Molecular Group of Fuxin Mixture in Treating Heart Failure Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1158111
Modern Language Association (MLA)
Yu, Yi-ding…[et al.]. To Explore the Mechanism and Equivalent Molecular Group of Fuxin Mixture in Treating Heart Failure Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1158111
American Medical Association (AMA)
Yu, Yi-ding& Xiu, Yi-ping& Li, Yang-fan& Xue, Yi-tao. To Explore the Mechanism and Equivalent Molecular Group of Fuxin Mixture in Treating Heart Failure Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1158111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158111