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Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium
Joint Authors
Kong, Su-ping
Xiao, Ning
Shao, Ming-lu
Cui, Hua-feng
Zhang, Chang-yun
Yu, Hui-juan
Tan, Qi-wen
Li, Yang
Zhang, Xin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Acupuncture preconditioning was able to reduce the extent of ischaemia reperfusion (I/R) injury.
Previous studies have shown that electroacupuncture (EA) pretreatment at T4-T5 Jiaji (EX-B2) acupoints had cardioprotective effects against myocardial I/R injury.
However, the molecular mechanism remains inconclusive.
Methods.
Wistar rats were pretreated with electroacupuncture for 7 days at the Neiguan (PC6), T4-T5 Jiaji (EX-B2), Yanglingquan (GB34), and Quchi (LI11) acupoints, which belong to different meridians.
Then, we investigated the genome-wide gene expression profiles of rats prestimulated at these acupoints after I/R injury.
Results.
Our study revealed previously unknown cardioprotective roles of T4-T5 Jiaji (EX-B2) acupoints in the I/R progression.
The extent of myocardial injury was significantly decreased in the Jiaji group compared with the I/R group.
In addition, our data are among the first to link the EA preconditioning at Neiguan (PC6) acupoints and circadian rhythm in the I/R model.
Also, for the first time, we explored the meridian and acupoint specificity involved in EA pretreatment at the heart meridian, in which Yanglingquan and Quchi acupoints were selected as the control group for heart-divergent-meridian and nonheart-meridian acupoints.
Conclusions.
The present study suggested that EA pretreatment at Jiaji alters genome-wide gene expression and protects the rat myocardium against I/R injury, which are most likely through neurohumoral regulation.
American Psychological Association (APA)
Xiao, Ning& Li, Yang& Shao, Ming-lu& Cui, Hua-feng& Zhang, Chang-yun& Kong, Su-ping…[et al.]. 2020. Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158114
Modern Language Association (MLA)
Xiao, Ning…[et al.]. Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158114
American Medical Association (AMA)
Xiao, Ning& Li, Yang& Shao, Ming-lu& Cui, Hua-feng& Zhang, Chang-yun& Kong, Su-ping…[et al.]. Jiaji (EX-B2)-Based Electroacupuncture Preconditioning Attenuates Early Ischaemia Reperfusion Injury in the Rat Myocardium. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158114