Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease
Joint Authors
Li, Zheng
Yang, Yang
Jin, Xin
Jiao, Xinyi
Li, Jinjing
Liang, Liuyi
Ma, Yuanyuan
Liu, Rui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality.
The conventional therapies remain palliative and have various undesired effects.
Flavonoids from traditional Chinese medicine (TCM) have been proved to exert protective effects on COPD.
This review aims to illuminate the poly-pharmacological properties of flavonoids in treating COPD based on laboratory evidences and clinical data and points out possible molecular mechanisms.
Animal/laboratory studies and randomised clinical trials about administration of flavonoids from TCM for treating COPD from January 2010 to October 2020 were identified and collected, with the following terms: chronic obstructive pulmonary disease or chronic respiratory disease or inflammatory lung disease, and flavonoid or nature product or traditional Chinese medicine.
Pharmacokinetic studies and external application treatment were excluded.
A total of 15 flavonoid compounds were listed.
Flavonoids could inhibit inflammation, oxidative stress, and cellular senescence, restore corticosteroid sensitivity, improve pulmonary histology, and boost pulmonary function through regulating multiple targets and signaling pathways, which manifest that flavonoids are a group of promising natural products for COPD.
Nevertheless, most studies remain in the research phase of animal testing, and further clinical applications should be carried out.
American Psychological Association (APA)
Yang, Yang& Jin, Xin& Jiao, Xinyi& Li, Jinjing& Liang, Liuyi& Ma, Yuanyuan…[et al.]. 2020. Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1158146
Modern Language Association (MLA)
Yang, Yang…[et al.]. Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1158146
American Medical Association (AMA)
Yang, Yang& Jin, Xin& Jiao, Xinyi& Li, Jinjing& Liang, Liuyi& Ma, Yuanyuan…[et al.]. Advances in Pharmacological Actions and Mechanisms of Flavonoids from Traditional Chinese Medicine in Treating Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1158146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158146