Rosanortriterpenes A–B, Two Promising Agents from Rosa laevigata var. leiocapus, Alleviate Inflammatory Responses and Liver Fibrosis in In Vitro Cell Models
Joint Authors
Yuan, Jie
Li, Bai-Lin
Hu, Juan-Juan
Xie, Jin-Dan
Ni, Chen
Liang, Hui-Jun
Li, Qian-Ran
Wu, Jie-Wei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rosanortriterpenes A–B (RTA and RTB), two nortriterpenoids, are characteristic constituents in the fruits of Rosa laevigata var.
leiocapus.
However, pharmacological studies on these compounds are still scarce.
In the present study, we aim to investigate the anti-inflammatory mechanisms associated with the effects of RTA–B in RAW264.7 macrophages and LO2 cells by detecting cell viabilities, nitric oxide (NO) production, tumour necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) production.
Simultaneously, the anti-inflammatory action mechanisms of these two compounds were illustrated through western blot assay.
Besides, the antihepatic fibrosis activities of these compounds have also been explored.
The results demonstrated that RTA and RTB inhibited the production of NO, TNF-α, and IL-6 and suppressed liver fibrosis.
RTA and RTB treatment also greatly inhibited the activation of NF-kappaB (NF-κB) pathway.
Our study confirmed the promising anti-inflammatory and anti-liver fibrosis actions of RTA–B, suggesting that they might be developed as alternative and promising drugs for the treatment of hepatic inflammatory and fibrotic diseases.
American Psychological Association (APA)
Li, Bai-Lin& Hu, Juan-Juan& Xie, Jin-Dan& Ni, Chen& Liang, Hui-Jun& Li, Qian-Ran…[et al.]. 2020. Rosanortriterpenes A–B, Two Promising Agents from Rosa laevigata var. leiocapus, Alleviate Inflammatory Responses and Liver Fibrosis in In Vitro Cell Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158153
Modern Language Association (MLA)
Li, Bai-Lin…[et al.]. Rosanortriterpenes A–B, Two Promising Agents from Rosa laevigata var. leiocapus, Alleviate Inflammatory Responses and Liver Fibrosis in In Vitro Cell Models. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158153
American Medical Association (AMA)
Li, Bai-Lin& Hu, Juan-Juan& Xie, Jin-Dan& Ni, Chen& Liang, Hui-Jun& Li, Qian-Ran…[et al.]. Rosanortriterpenes A–B, Two Promising Agents from Rosa laevigata var. leiocapus, Alleviate Inflammatory Responses and Liver Fibrosis in In Vitro Cell Models. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158153
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158153