A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis
Joint Authors
Qiao, Bo
Wu, Yueying
Li, Xiaoya
Xu, Zhenyuan
Duan, Weigang
Hu, Yanan
Jia, Wenqing
Fan, Qiuyang
Xing, Haijing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Objective.
Yifei Sanjie Formula (YFSJF) is an effective formula on pulmonary fibrosis (PF), which has been used in clinic for more than 30 years.
In order to investigate the molecular mechanism of YFSJF in treating PF, network pharmacology was used to predict the cooperative ingredients and associated pathways.
Methods.
Firstly, we collected potential active ingredients of YFSJF by TCMSP databases.
Secondly, we obtained PF-associated targets through OMIM and Genecards database.
Finally, metascape was applied for the analysis of GO terms and KEGG pathways.
Results.
We screened out 76 potential active ingredients and 98 associated proteins.
A total of 5715 items were obtained by GO enrichment analysis (P<0.05), including 4632 biological processes, 444 cellular components, and 639 molecular functions.
A total of 143 related KEGG pathways were enriched (P<0.05), including IL-17 signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, calcium signaling pathway, TH17 cell differentiation, HIF-1 signaling pathway, and PI3K-Akt signaling pathway.
Conclusion.
YFSJF can interfere with immune and inflammatory response through multiple targets and pathways, which has a certain role in the treatment of PF.
This study lays a foundation for future experimental research.
American Psychological Association (APA)
Qiao, Bo& Wu, Yueying& Li, Xiaoya& Xu, Zhenyuan& Duan, Weigang& Hu, Yanan…[et al.]. 2020. A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1158200
Modern Language Association (MLA)
Qiao, Bo…[et al.]. A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1158200
American Medical Association (AMA)
Qiao, Bo& Wu, Yueying& Li, Xiaoya& Xu, Zhenyuan& Duan, Weigang& Hu, Yanan…[et al.]. A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1158200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158200