Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis
Joint Authors
Zhang, Qiang
He, Yan-Ming
Yuan, Sha-Sha
Zheng, Min
He, Xiao-Li
Li, Hong-Shan
Liu, Cheng-Hao
Fan, Chao-Hua
Li, Yun-Hao
Yang, Hong-Jie
Zhou, Ping
Zhang, Dan
Zhang, Zeng
Wang, Yan-Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Yueju, a famous classic Chinese prescription, has been extensively used in treating depression syndromes for hundreds of years.
Recent studies have reported that Yueju showed good effects in treating metabolic diseases, such as obesity and hyperlipidemia.
Nonalcoholic steatohepatitis (NASH), which leads to cirrhosis and severe cardiovascular diseases, is closely linked to obesity and abnormal lipid metabolism.
In this study, Yueju could decrease the levels of alanine aminotransferase, aspartate transaminase, triglyceride, cholesterol, and low-density lipoprotein-C but increase the high-density lipoprotein-C in the serum of the NASH rat model induced by high-fat and high-cholesterol diet.
Yueju could alleviate hepatosteatosis by increasing the phosphorylation of acetyl-CoA carboxylase and inhibiting the expression of fatty acid synthase and stearoyl-CoA desaturase 1.
Yueju downregulated the expression of α-smooth muscle actin and collagen type 1A1, ameliorating the liver fibrilization.
Yueju could also protect the hepatocytes from apoptosis by upregulating antiapoptosis protein Bcl-2 and X-linked inhibitor of apoptosis protein and downregulating apoptotic proteins Bax and cleaved poly ADP-ribose polymerase.
Thus, Yueju could improve liver function, regulate lipid metabolism, alleviate hepatosteatosis and fibrosis, and protect hepatocytes from apoptosis against NASH.
Yueju may be used as an alternative effective medicine for NASH treatment.
American Psychological Association (APA)
He, Xiao-Li& He, Yan-Ming& Zhang, Dan& Li, Hong-Shan& Zhang, Qiang& Yuan, Sha-Sha…[et al.]. 2020. Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158205
Modern Language Association (MLA)
He, Xiao-Li…[et al.]. Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1158205
American Medical Association (AMA)
He, Xiao-Li& He, Yan-Ming& Zhang, Dan& Li, Hong-Shan& Zhang, Qiang& Yuan, Sha-Sha…[et al.]. Efficacy and Mechanism of a Chinese Classic Prescription of Yueju in Treating Nonalcoholic Steatohepatitis and Protecting Hepatocytes from Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158205
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158205