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Network Pharmacology-Based Study on the Mechanism of Scutellariae Radix for Hepatocellular Carcinoma Treatment
Joint Authors
Wang, Qian
Peng, Can
Liang, Yan
Jiang, Peng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is a malignant tumor without effective therapeutic drugs for most patients in advanced stages.
Scutellariae Radix (SR) is a well-known anti-inflammatory and anticarcinogenic herbal medicine.
However, the mechanism of SR against HCC remains to be clarified.
In the present study, network pharmacology was utilized to characterize the mechanism of SR on HCC.
The active components of SR and their targets were collected from the traditional Chinese medicine systems pharmacology database and the traditional Chinese medicine integrated database.
HCC-related targets were acquired from the liver cancer databases OncoDB.HCC and Liverome.
The gene ontology and the Kyoto Encyclopedia of Genes and Genomes pathway were analyzed using the Database for Annotation, Visualization, and Integrated Discovery.
Component-component target and protein-protein interaction networks were set up.
A total of 143 components of SR were identified, and 37 of them were considered as candidate active components.
Fifty targets corresponding to 29 components of SR were mapped with targets of HCC.
Functional enrichment analysis indicated that SR exerted an antihepatocarcinoma effect by regulating pathways in cancer, hepatitis B, viral carcinogenesis, and PI3K-Akt signaling.
The holistic approach of network pharmacology can provide novel insights into the mechanistic study and therapeutic drug development of SR for HCC treatment.
American Psychological Association (APA)
Wang, Qian& Liang, Yan& Peng, Can& Jiang, Peng. 2020. Network Pharmacology-Based Study on the Mechanism of Scutellariae Radix for Hepatocellular Carcinoma Treatment. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158241
Modern Language Association (MLA)
Wang, Qian…[et al.]. Network Pharmacology-Based Study on the Mechanism of Scutellariae Radix for Hepatocellular Carcinoma Treatment. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1158241
American Medical Association (AMA)
Wang, Qian& Liang, Yan& Peng, Can& Jiang, Peng. Network Pharmacology-Based Study on the Mechanism of Scutellariae Radix for Hepatocellular Carcinoma Treatment. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158241