A Comprehensive Toxicological Assessment of Fulvic Acid
Joint Authors
Dai, Chongshan
Xiao, Xilong
Yuan, Yonglei
Sharma, Gaurav
Tang, Shusheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Fulvic acid (FA), a humic substance, has several nutraceutical properties, including anti-inflammation, antimicrobial, and immune regulation abilities.
However, systematic safety assessment remains insufficient.
In the present study, a battery of toxicological studies was conducted per internationally accepted standards to investigate the genotoxicity and repeated-dose oral toxicity of FA.
Sprague-Dawley (SD) rats or ICR mice were used.
Compared to the control group, there were no significant changes (all p>0.05) in all FA treatment groups in the bacterial reverse mutation test, in vitro mammalian chromosome aberration test, in vivo sperm shape abnormality assay, and in vivo mouse micronucleus assay.
The acute toxicity test showed that no mortality or toxic effect was observed following oral administration of the maximum dose of 5,000 mg/kg BW/day to mice or rats.
A 60-day subchronic study was conducted at 0 (control), 200, 1,000, and 5,000 mg/kg/day.
Compared to the control group, there were no significant changes (all p>0.05) in the body weights, feed consumption, clinical signs, hematology, clinical chemistry, organ weights, or histopathology examinations.
In conclusion, the no-observed-adverse-effect-level (NOAEL) of FA supplementation from the 60-day study was determined to be 5,000 mg/kg body weight/day, the highest dose tested.
Our findings suggest that the oral administration of FA may have higher safety.
American Psychological Association (APA)
Dai, Chongshan& Xiao, Xilong& Yuan, Yonglei& Sharma, Gaurav& Tang, Shusheng. 2020. A Comprehensive Toxicological Assessment of Fulvic Acid. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158249
Modern Language Association (MLA)
Dai, Chongshan…[et al.]. A Comprehensive Toxicological Assessment of Fulvic Acid. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1158249
American Medical Association (AMA)
Dai, Chongshan& Xiao, Xilong& Yuan, Yonglei& Sharma, Gaurav& Tang, Shusheng. A Comprehensive Toxicological Assessment of Fulvic Acid. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158249
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158249