Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer
Joint Authors
Mustafi, Devkumar
Leinroth, Abby
Fan, Xiaobing
Markiewicz, Erica
Zamora, Marta
Mueller, Jeffrey
Conzen, Suzanne D.
Karczmar, Gregory S.
Source
International Journal of Biomedical Imaging
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Breast cancer is a major cause of morbidity and mortality in Western women.
Tumor neoangiogenesis, the formation of new blood vessels from pre-existing ones, may be used as a prognostic marker for cancer progression.
Clinical practice uses dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to detect cancers based on increased blood flow and capillary permeability.
However, DCE-MRI requires repeated injections of contrast media.
Therefore we explored the use of noninvasive time-of-flight (TOF) MR angiography for serial studies of mouse mammary glands to measure the number and size of arteries feeding mammary glands with and without cancer.
Virgin female C3(1) SV40 TAg mice (n=9), aged 18-20 weeks, were imaged on a 9.4 Tesla small animal scanner.
Multislice T2-weighted (T2W) images and TOF-MRI angiograms were acquired over inguinal mouse mammary glands.
The data were analyzed to determine tumor burden in each mammary gland and the volume of arteries feeding each mammary gland.
After in vivo MRI, inguinal mammary glands were excised and fixed in formalin for histology.
TOF angiography detected arteries with a diameter as small as 0.1 mm feeding the mammary glands.
A significant correlation (r=0.79; p< 0.0001) was found between tumor volume and the arterial blood volume measured in mammary glands.
Mammary arterial blood volumes ranging from 0.08 mm3 to 3.81 mm3 were measured.
Tumors and blood vessels found on in vivo T2W and TOF images, respectively, were confirmed with ex vivo histological images.
These results demonstrate increased recruitment of arteries to mammary glands with cancer, likely associated with neoangiogenesis.
Neoangiogenesis may be detected by TOF angiography without injection of contrast agents.
This would be very useful in mouse models where repeat placement of I.V.
lines is challenging.
In addition, analogous methods could be tested in humans to evaluate the vasculature of suspicious lesions without using contrast agents.
American Psychological Association (APA)
Mustafi, Devkumar& Leinroth, Abby& Fan, Xiaobing& Markiewicz, Erica& Zamora, Marta& Mueller, Jeffrey…[et al.]. 2019. Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer. International Journal of Biomedical Imaging،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1158313
Modern Language Association (MLA)
Mustafi, Devkumar…[et al.]. Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer. International Journal of Biomedical Imaging No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1158313
American Medical Association (AMA)
Mustafi, Devkumar& Leinroth, Abby& Fan, Xiaobing& Markiewicz, Erica& Zamora, Marta& Mueller, Jeffrey…[et al.]. Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer. International Journal of Biomedical Imaging. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1158313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158313