Prophylactic Effect of Lactobacillus plantarum YS4 on Oxazolone-Induced Colitis in BALBc Mice
Joint Authors
Yi, Ruokun
Zhao, Xin
Mu, Jianfei
Tan, Fang
Suo, Huayi
Li, Wenfeng
Zhou, Xianrong
Xie, Peng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the present research, the effects of Lactobacillus plantarum YS4 (LP-YS4) on colitis were tested in an oxazolone-induced mouse model.
BALB/c mice were induced by oxazolone and then treated with LP-YS4.
The serum levels of mice were analyzed using commercial kits and the protein and mRNA expression levels of mouse colon tissue were detected by Western blotting and qPCR assay, respectively.
The results demonstrated that LP-YS4 significantly (P<0.05) increased the colon length and ratio of colon weight/length in mice with colitis and attenuated the negative effects of colitis.
The results also showed that treatment with LP-YS4 significantly reduced the serum concentrations of ET-1, SP, and IL-10 while significantly increasing those of SS, VIP, and IL-2 in colitis mice (P<0.05).
In addition, LP-YS4 significantly increased the activities of GSH and SOD while decreasing those of MPO and MDA in the colon tissue of colitis mice (P<0.05).
LP-YS4 also significantly upregulated the mRNA and protein expression of c-Kit, eNOS, nNOSe, and SCF in colitis mice while significantly downregulating the relative expression of iNOS.
In summary, LP-YS4 could reduce the negative effects of colitis, and such effects were better than those of the common probiotic Lactobacillus bulgaricus.
American Psychological Association (APA)
Yi, Ruokun& Tan, Fang& Suo, Huayi& Li, Wenfeng& Zhou, Xianrong& Mu, Jianfei…[et al.]. 2020. Prophylactic Effect of Lactobacillus plantarum YS4 on Oxazolone-Induced Colitis in BALBc Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158314
Modern Language Association (MLA)
Yi, Ruokun…[et al.]. Prophylactic Effect of Lactobacillus plantarum YS4 on Oxazolone-Induced Colitis in BALBc Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1158314
American Medical Association (AMA)
Yi, Ruokun& Tan, Fang& Suo, Huayi& Li, Wenfeng& Zhou, Xianrong& Mu, Jianfei…[et al.]. Prophylactic Effect of Lactobacillus plantarum YS4 on Oxazolone-Induced Colitis in BALBc Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158314