Network Pharmacology-Based Approach to Investigate the Mechanisms of Mahai Capsules in the Treatment of Cardiovascular Diseases
Joint Authors
Shi, Minjuan
Li, Bo
Yuan, Qiuzhen
Gan, Xuefeng
Ren, Xiao
Jiang, Shanshan
Liu, Zhuo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Mahai capsules (MHC) have been deemed to be an effective herb combination for treatment of cardiovascular diseases (CVD) development and improvement of the life quality of CVD patients.
To systematically explore the mechanisms of MHC in CVD, a network pharmacology approach mainly comprising target prediction, network construction, biological process and pathway analysis, and related diseases was adopted in this study.
Methods.
We collected the bioactive compounds and potential targets of MHC through the TCMSP servers.
Candidate targets related to CVD were collected from Therapeutic Targets Database and PharmGkb database and analyzed using ClueGO plugin in Cytoscape.
KEGG pathway was enriched and analyzed through the EnrichR platform, and protein-protein interaction networks were calculated by STRING platform.
The compound-target, target-disease, and compound-target-disease networks were constructed using Cytoscape.
Results.
A total of 303 targets of the 57 active ingredients in MHC were obtained.
The network analysis showed that PTGS2, PTGS1, HSP90, Scn1a, estrogen receptor, calmodulin, and thrombin were identified as key targets of MHC in the treatment of CVD.
The functional enrichment analysis indicated that MHC probably produced the therapeutic effects against CVD by synergistically regulating many biological pathways, such as PI3K-Akt, TNF, HIF-1, FoxO, apoptosis, calcium, T-cell receptor, VEGF, and NF-kappa B signaling pathway.
Conclusions.
In summary, the analysis of the complete profile of the pharmacological properties, as well as the elucidation of targets, networks, and pathways, can further illuminate that the underlying mechanisms of MHC in CVD might be strongly associated with its synergic regulation of inflammation, apoptosis, and immune function, and provide new clues for its future development of therapeutic strategies and basic research.
American Psychological Association (APA)
Shi, Minjuan& Li, Bo& Yuan, Qiuzhen& Gan, Xuefeng& Ren, Xiao& Jiang, Shanshan…[et al.]. 2020. Network Pharmacology-Based Approach to Investigate the Mechanisms of Mahai Capsules in the Treatment of Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1158394
Modern Language Association (MLA)
Shi, Minjuan…[et al.]. Network Pharmacology-Based Approach to Investigate the Mechanisms of Mahai Capsules in the Treatment of Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1158394
American Medical Association (AMA)
Shi, Minjuan& Li, Bo& Yuan, Qiuzhen& Gan, Xuefeng& Ren, Xiao& Jiang, Shanshan…[et al.]. Network Pharmacology-Based Approach to Investigate the Mechanisms of Mahai Capsules in the Treatment of Cardiovascular Diseases. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1158394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158394