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Secretory IgA in Mucosa of Pharynx and Larynx Plays an Important Role against Influenza A Virus Infection in Kidney Yang Deficiency Syndrome Model
Joint Authors
Zhao, Shaozhe
Rong, Rong
Yang, Yong
Yuan, Lei
Li, Yi
Liu, Longchan
Luo, Zixin
Lv, Qingtao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Influenza virus poses a major threat to human health and has serious morbidity and mortality which commonly occurs in high-risk populations.
Pharynx and larynx of the upper respiratory tract mucosa is the first defense line against influenza virus infection.
However, the ability of the pharynx and larynx organ to eliminate the influenza pathogen is still not clear under different host conditions.
Methods.
In this study, a mouse model of kidney yang deficiency syndrome (KYDS) was used to mimic high-risk peoples.
Two different methods of influenza A (H1N1) virus infection by nasal dropping or tracheal intubation were applied to these mice, which were divided into four groups: normal intubation (NI) group, normal nasal dropping (ND) group, model intubation (MI) group, and model nasal dropping (MD) group.
The normal control (NC) group was used as a negative control.
Body weight, rectal temperature, and survival rate were observed every day.
Histopathologic changes, visceral index, gene expressions of H1N1, cytokine expressions, secretory IgA (SIgA) antibodies of tracheal lavage fluids in the upper respiratory tract, and bronchoalveolar lavage fluids were analyzed by ELISA.
Results.
The MD group had an earlier serious morbidity and mortality than the others.
MI and NI groups became severe only in the 6th to 7th day after infection.
The index of the lung increased significantly in NI, MI, and MD groups.
Conversely, indices of the thymus and spleen increased significantly in NC and ND groups.
H&E staining showed severe tissue lesions in MD, MI, and NI groups.
H1N1 gene expressions were higher in the MD group compared with the MI group on the 3rd day; however, the MD group decreased significantly on the 7th day.
IL-6 levels increased remarkably, and SIgA expressions decreased significantly in the MD group compared with the NC group.
Conclusions.
SIgA secretions are influenced directly by different conditions of the host in the pharynx and larynx in the upper respiratory tract mucosa.
In the KYDS virus disease mode, SIgA expressions could be inhibited severely, which leads to serious morbidity and mortality after influenza A virus infection.
The SIgA expressions of the pharynx and larynx would be an important target in high-risk populations against the influenza A virus for vaccine or antiviral drugs research.
American Psychological Association (APA)
Zhao, Shaozhe& Yuan, Lei& Li, Yi& Liu, Longchan& Luo, Zixin& Lv, Qingtao…[et al.]. 2020. Secretory IgA in Mucosa of Pharynx and Larynx Plays an Important Role against Influenza A Virus Infection in Kidney Yang Deficiency Syndrome Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158459
Modern Language Association (MLA)
Zhao, Shaozhe…[et al.]. Secretory IgA in Mucosa of Pharynx and Larynx Plays an Important Role against Influenza A Virus Infection in Kidney Yang Deficiency Syndrome Model. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1158459
American Medical Association (AMA)
Zhao, Shaozhe& Yuan, Lei& Li, Yi& Liu, Longchan& Luo, Zixin& Lv, Qingtao…[et al.]. Secretory IgA in Mucosa of Pharynx and Larynx Plays an Important Role against Influenza A Virus Infection in Kidney Yang Deficiency Syndrome Model. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158459