Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue
Joint Authors
Lee, Seung Eun
Lee, Yuan Yee
Kim, Minki
Irfan, Muhammad
Yuk, Heung Joo
Kim, Dong-Seon
Kim, Seung-Hyung
Kim, Suk
Kim, Sung-Dae
Rhee, Man Hee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The bark of Ulmus parvifolia Jacq.
(UP) was traditionally used as a diuretic and to treat intestinal inflammation.
With modern evidence of the correlation of diuretics, gut inflammation, and obesity, our study has shown the antiobesity effects of the bark of UP.
UP treatment reduced lipid production and adipogenic genes in vitro.
In vivo studies revealed that UP 100 mg/kg and UP 300 mg/kg treatment significantly reduced mouse weight without reducing food intake, indicating increased energy expenditure.
UP significantly reduced the weight of epididymal and subcutaneous adipose tissue and decreased liver weight.
Histological analysis revealed improvement in the progression of nonalcoholic fatty liver disease and epididymal white adipose tissue hypertrophy induced by a HFD.
Real-Time PCR of epididymal adipose tissue revealed significant increases of uncoupling protein-1 (UCP-1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) expression after UP 300 mg/kg treatments.
Phosphorylation of AMP-activated protein α (AMPKα) was increased, while phosphorylation of Acetyl-CoA Carboxylase (ACC) was reduced.
Our findings reveal the ability of UP to reduce the occurrence of obesity through increased browning of white adipose tissue via increased AMPKα, PPARγ, PGC-1α, and UCP-1 expression.
American Psychological Association (APA)
Lee, Yuan Yee& Kim, Minki& Irfan, Muhammad& Yuk, Heung Joo& Kim, Dong-Seon& Lee, Seung Eun…[et al.]. 2020. Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1158466
Modern Language Association (MLA)
Lee, Yuan Yee…[et al.]. Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1158466
American Medical Association (AMA)
Lee, Yuan Yee& Kim, Minki& Irfan, Muhammad& Yuk, Heung Joo& Kim, Dong-Seon& Lee, Seung Eun…[et al.]. Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1158466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158466