Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients
Joint Authors
Nordin, Norshariza
Yahya, Mohd Jokha
Ismail, Patimah binti
Akim, Abdah binti Md
Yusuf, Wan Shaariah binti Md.
Adam, Noor Lita binti
Yusoff, Maryam Jamielah
Source
International Journal of Chronic Diseases
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The unique variants or biomarkers of individuals help to understand the pathogenesis as well as the potential risk of individuals or patients to diabetic nephropathy (DN).
The aim of this study was to investigate the association of a genetic polymorphism of monocyte chemoattractant protein-1 (CCL2-rs3917887), chemokine receptor 5 (CCR5-rs1799987), engulfment and cell mortality (ELMO1-rs74130), and interleukin-8 (IL8-rs4073) with the development of DN among Malaysian type 2 diabetes mellitus (T2DM) patients.
More than one thousand diabetic patients were examined and a total of 652 T2DM patients were tested comprising 227 Malays (nonnephrotic=96 and nephrotic=131), 203 Chinese (nonnephrotic=95 and nephrotic=108), and 222 Indians (nonnephrotic=136 and nephrotic=86).
DNA Sequenom mass ARRAY was employed to identify polymorphisms in CCL2, CCR5, ELMO1, and IL8 genes.
DNA was extracted from the secondary blood samples taken from the T2DM patients.
The alleles and genotypes were tested using four genetic models and the best mode of inheritance was chosen.
CCR5 rs1799987 (G>A) showed strong association with the development of diabetic nephropathy only among the Chinese with OR=6.71 (2.55-17.68) 95% CI while IL8 rs4073 (T>A) showed association with nephropathy only among the Indians with OR=1.57 (0.66-3.71) 95% CI.
The additive model was the best model for the mode of inheritance of all the genes.
The contribution of genetic variants differs across ethnic groups or background.
Further studies which involve environmental risk factors should be taken into consideration.
American Psychological Association (APA)
Yahya, Mohd Jokha& Ismail, Patimah binti& Nordin, Norshariza& Akim, Abdah binti Md& Yusuf, Wan Shaariah binti Md.& Adam, Noor Lita binti…[et al.]. 2019. Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients. International Journal of Chronic Diseases،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1158554
Modern Language Association (MLA)
Yahya, Mohd Jokha…[et al.]. Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients. International Journal of Chronic Diseases No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1158554
American Medical Association (AMA)
Yahya, Mohd Jokha& Ismail, Patimah binti& Nordin, Norshariza& Akim, Abdah binti Md& Yusuf, Wan Shaariah binti Md.& Adam, Noor Lita binti…[et al.]. Association of CCL2, CCR5, ELMO1, and IL8 Polymorphism with Diabetic Nephropathy in Malaysian Type 2 Diabetic Patients. International Journal of Chronic Diseases. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1158554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158554