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Jisuikang Promotes the Repair of Spinal Cord Injury in Rats by Regulating NgRRhoAROCK Signal Pathway
Joint Authors
Zhou, Yuxin
Sun, Jie
Wu, Chengjie
Tu, Pengcheng
Yang, Guanglu
Zheng, Suyang
Pan, Yalan
Guo, Yang
Ma, Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Jisuikang (JSK) is an herbal formula composed of many kinds of traditional Chinese medicine, which has been proved to be effective in promoting the rehabilitation of patients with spinal cord injury (SCI) after more than ten years of clinical application.
However, the mechanisms of JSK promoting nerve regeneration are yet to be clarified.
The aim of this study was to investigate the effects of JSK protecting neurons, specifically the regulation of NgR/RhoA/ROCK signal pathway.
The motor function of rats was evaluated by the BBB score and inclined plate test, Golgi staining and transmission electron microscope were used to observe the microstructure of nerve tissue, and fluorescence double-labeling method was used to detect neuronal apoptosis.
In this study, we found that JSK could improve the motor function of rats with SCI, protect the microstructure (mitochondria, endoplasmic reticulum, and dendritic spine) of neurons, and reduce the apoptosis rate of neurons in rats with SCI.
In addition, JSK could inhibit the expression of Nogo receptor (NgR) in neurons and the NgR/RhoA/ROCK signal pathway in rats with SCI.
These results indicated JSK could improve the motor function of rats with SCI by inhibiting the NgR/RhoA/ROCK signal pathway, which suggests the potential applicability of JSK as a nerve regeneration agent.
American Psychological Association (APA)
Wu, Chengjie& Zhou, Yuxin& Tu, Pengcheng& Yang, Guanglu& Zheng, Suyang& Pan, Yalan…[et al.]. 2020. Jisuikang Promotes the Repair of Spinal Cord Injury in Rats by Regulating NgRRhoAROCK Signal Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1158600
Modern Language Association (MLA)
Wu, Chengjie…[et al.]. Jisuikang Promotes the Repair of Spinal Cord Injury in Rats by Regulating NgRRhoAROCK Signal Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1158600
American Medical Association (AMA)
Wu, Chengjie& Zhou, Yuxin& Tu, Pengcheng& Yang, Guanglu& Zheng, Suyang& Pan, Yalan…[et al.]. Jisuikang Promotes the Repair of Spinal Cord Injury in Rats by Regulating NgRRhoAROCK Signal Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1158600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158600