Could Xuebijing Injection Reduce the Mortality of Severe Pneumonia Patients? A Systematic Review and Meta-Analysis
Joint Authors
Zhu, Jia
Wang, Juan
Guo, Jie
Wang, Qian
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background and Aim.
Xuebijing injection (XBJ) is a Chinese traditional medicine preparation, mainly made from Carthamus tinctorius flowers (Honghua in Chinese), Paeonia lactiflora roots (Chishao), Ligusticum chuanxiong rhizomes (Chuanxiong), Salvia miltiorrhiza roots (Danshen), and Angelica sinensis roots (Danggui).
It can reduce inflammation and regulate blood coagulation and immune function.
XBJ has been used in severe pneumonia patients in China.
Whether it can reduce the mortality of patients is still controversial.
This study aimed to analyze the effectiveness of XBJ in the treatment of severe pneumonia.
Methods.
Databases including PubMed, Cochrane Library, Web of Science, Embase, CNKI, WanFang, and VIP were searched, from inception to February 2020, to identify randomized controlled trials (RCTs) about XBJ combined with western medicine treatment in treating severe pneumonia.
Literature screening, data extraction, and methodological quality assessment were carried out by two researchers back-to-back.
RevMan 5.3 software was used for statistical analysis.
Results.
A total of 21 articles involving 2072 patients were included.
The meta-analysis showed that treatment combined with XBJ has better efficiency compared with western medicine treatment alone.
It could also decrease 28-day mortality; shorten the length of intensive care unit (ICU) stay time and mechanical ventilation time; and reduce the levels of C-reactive protein (CRP), procalcitonin (PCT), white blood cell (WBC), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and D-dimer in the serum of patients.
The incidence of adverse reactions did not increase significantly.
Conclusion.
XBJ combined with western medicine treatment has significant clinical efficacy and no obvious adverse reactions.
A dose of 100 ml bid is recommended to reduce 28-day mortality.
The conclusion needs to be further verified with larger-sample size and higher-quality RCTs.
American Psychological Association (APA)
Wang, Juan& Zhu, Jia& Guo, Jie& Wang, Qian. 2020. Could Xuebijing Injection Reduce the Mortality of Severe Pneumonia Patients? A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158636
Modern Language Association (MLA)
Wang, Juan…[et al.]. Could Xuebijing Injection Reduce the Mortality of Severe Pneumonia Patients? A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1158636
American Medical Association (AMA)
Wang, Juan& Zhu, Jia& Guo, Jie& Wang, Qian. Could Xuebijing Injection Reduce the Mortality of Severe Pneumonia Patients? A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1158636
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158636