Longshengzhi Capsules Improve Ischemic Stroke Outcomes and Reperfusion Injury via the Promotion of Anti-Inflammatory and Neuroprotective Effects in MCAOR Rats
Joint Authors
Zhang, Yuyan
Zhou, Jing
Chen, Simiao
Chen, Weiyan
Yang, Weinan
Zhang, Lincheng
Yao, Qigu
Chen, Haihong
He, Lan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Stroke is the leading cause of death in the elderly.
Traditional Chinese medicine provides an exciting strategy for treating stroke.
Previous reports indicated that Longshengzhi capsules (LSZ), a modified Chinese formula, reduced formed thrombi and oxidative stress and were promising in the clinical treatment of ischemic stroke.
However, the specific therapeutic effect and mechanism of LSZ are still ambiguous.
This study aimed to define the effects of LSZ on proinflammatory mediators and neuroprotective effects on middle cerebral artery occlusion and refusion (MCAO/R) rats.
Rats were treated with different doses of LSZ (0.54, 1.62, and 4.32 g/(kg·d)) in a week after model building.
LSZ could improve the survival rate, ischemic stroke outcome, and infarct volume.
In addition, significant decrease was observed in reactive oxygen species (ROS) levels and inflammatory factor levels in LSZ-treated groups, concomitant with increase in activities of superoxide dismutase (SOD), neurosynaptic remodeling, and decrease in brain edema.
It is proposed that LSZ has anti-inflammatory and neuroprotective effects resulting in downregulating matrix metalloproteinase 2/9 (MMP-2/9) and vascular endothelial growth factor (VEGF) and nuclear factor kappa-B (NF-κB) and upregulating microtubule-associated protein-2 (Map-2) and growth-associated protein-43 (GAP-43) via p38 MAPK and HIF-1α signaling pathways in MCAO/R rats.
This study provides potential evidences that p38 MAPK and HIF-1α/VEGF signaling pathways play significant roles in the anti-inflammatory and neuroprotective effects of LSZ.
American Psychological Association (APA)
Yang, Weinan& Zhang, Lincheng& Chen, Simiao& Yao, Qigu& Chen, Haihong& Zhou, Jing…[et al.]. 2020. Longshengzhi Capsules Improve Ischemic Stroke Outcomes and Reperfusion Injury via the Promotion of Anti-Inflammatory and Neuroprotective Effects in MCAOR Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1158666
Modern Language Association (MLA)
Yang, Weinan…[et al.]. Longshengzhi Capsules Improve Ischemic Stroke Outcomes and Reperfusion Injury via the Promotion of Anti-Inflammatory and Neuroprotective Effects in MCAOR Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1158666
American Medical Association (AMA)
Yang, Weinan& Zhang, Lincheng& Chen, Simiao& Yao, Qigu& Chen, Haihong& Zhou, Jing…[et al.]. Longshengzhi Capsules Improve Ischemic Stroke Outcomes and Reperfusion Injury via the Promotion of Anti-Inflammatory and Neuroprotective Effects in MCAOR Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1158666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158666