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Extract of Pogostemon cablin Possesses Potent Anticancer Activity against Colorectal Cancer Cells In Vitro and In Vivo
Joint Authors
Chen, Yi-Ting
Chien, Ju-Huei
Lee, Shan-Chih
Tsai, Nu-Man
Chang, Kai-Fu
Huang, Xiao-Fan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-09-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Pogostemon cablin (PCa), an herb used in traditional Chinese medicine, is routinely used in the amelioration of different types of gastrointestinal discomfort.
However, the mechanisms underlying the cancer suppression activity of PCa in colorectal cancer (CRC) cells have yet to be clarified.
The aim of this study was to investigate the anticancer effects of PCa, specifically the induction of apoptosis in CRC cells.
The growth inhibition curve of CRC cells following exposure to PCa was detected by an MTT assay.
Moreover, PCa combined with 5-FU revealed a synergic effect of decreased cell viability.
PCa inhibited cell proliferation and induced cell cycle arrest at the G0/G1 phase and cell apoptosis through regulation of associated protein expression.
An in vivo study showed that PCa suppressed the growth of CRC via induction of cell apoptosis with no significant change in body weight or organ histology.
Our results demonstrated that PCa inhibits the growth of CRC cells and induces apoptosis in vitro and in vivo, which suggests the potential applicability of PCa as an anticancer agent.
American Psychological Association (APA)
Chien, Ju-Huei& Lee, Shan-Chih& Chang, Kai-Fu& Huang, Xiao-Fan& Chen, Yi-Ting& Tsai, Nu-Man. 2020. Extract of Pogostemon cablin Possesses Potent Anticancer Activity against Colorectal Cancer Cells In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158701
Modern Language Association (MLA)
Chien, Ju-Huei…[et al.]. Extract of Pogostemon cablin Possesses Potent Anticancer Activity against Colorectal Cancer Cells In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1158701
American Medical Association (AMA)
Chien, Ju-Huei& Lee, Shan-Chih& Chang, Kai-Fu& Huang, Xiao-Fan& Chen, Yi-Ting& Tsai, Nu-Man. Extract of Pogostemon cablin Possesses Potent Anticancer Activity against Colorectal Cancer Cells In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1158701
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158701