Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on IschemiaReperfusion-Induced Kidney Injury in Male Rats
Joint Authors
Omidifar, Navid
Gheitasi, Izadpanah
Azizi, Arsalan
Doustimotlagh, Amir Hossein
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The most important cause of acute renal failure in normal kidneys is ischemia-reperfusion (I/R) injury.
The aim of the current study was to investigate the protective effects of Origanum majorana (OM) methanolic extract, carvacrol, and vitamin E on I/R-induced kidney injury in male rats.
Material and Method.
Thirty Wistar male rats were randomly allocated into 5 groups; sham, I/R, I/R + OM (300 mg/kg), I/R + carvacrol (75 mg/kg), and I/R + vitamin E (100 mg/kg).
Renal function markers, oxidant-antioxidant parameters, and histopathological examination were evaluated.
Results.
It was exhibited that the urea, creatinine, protein carbonyl, glomerular filtration rate, total thiol, ferric reducing antioxidant power, and histopathological changes markedly reversed in the treatment groups with OM or carvacrol in comparison to the I/R merely group.
Conclusion.
We conclude that OM extract or its ingredient, carvacrol, exerts renoprotective impacts in I/R-induced kidney injury possibly by scavenging free radicals and increasing antioxidant power.
American Psychological Association (APA)
Gheitasi, Izadpanah& Azizi, Arsalan& Omidifar, Navid& Doustimotlagh, Amir Hossein. 2020. Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on IschemiaReperfusion-Induced Kidney Injury in Male Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158728
Modern Language Association (MLA)
Gheitasi, Izadpanah…[et al.]. Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on IschemiaReperfusion-Induced Kidney Injury in Male Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158728
American Medical Association (AMA)
Gheitasi, Izadpanah& Azizi, Arsalan& Omidifar, Navid& Doustimotlagh, Amir Hossein. Renoprotective Effects of Origanum majorana Methanolic L and Carvacrol on IschemiaReperfusion-Induced Kidney Injury in Male Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158728