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Analysis of the Molecular Mechanisms of the Effects of Prunella vulgaris against Subacute Thyroiditis Based on Network Pharmacology
Joint Authors
Shen, Xin
Yang, Rui
An, Jianpeng
Zhong, Xia
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Prunella vulgaris (PV) has a long history of application in traditional Chinese and Western medicine as a remedy for the treatment of subacute thyroiditis (SAT).
This study applied network pharmacology to elucidate the mechanism of the effects of PV against SAT.
Components of the potential therapeutic targets of PV and SAT-related targets were retrieved from databases.
To construct a protein-protein interaction (PPI) network, the intersection of SAT-related targets and PV-related targets was input into the STRING platform.
Gene ontology (GO) analysis and KEGG pathway enrichment analysis were carried out using the DAVID database.
Networks were constructed by Cytoscape for visualization.
The results showed that a total of 11 compounds were identified according to the pharmacokinetic parameters of ADME.
A total of 126 PV-related targets and 2207 SAT-related targets were collected, and 83 overlapping targets were subsequently obtained.
The results of the KEGG pathway and compound-target-pathway (C-T-P) network analysis suggested that the anti-SAT effect of PV mainly occurs through quercetin, luteolin, kaempferol, and beta-sitosterol and is most closely associated with their regulation of inflammation and apoptosis by targeting the PIK3CG, MAPK1, MAPK14, TNF, and PTGS2 proteins and the PI3K-Akt and TNF signaling pathways.
The study demonstrated that quercetin, luteolin, kaempferol, and beta-sitosterol in PV may play a major role in the treatment of SAT, which was associated with the regulation of inflammation and apoptosis, by targeting the PI3K-Akt and TNF signaling pathways.
American Psychological Association (APA)
Shen, Xin& Yang, Rui& An, Jianpeng& Zhong, Xia. 2020. Analysis of the Molecular Mechanisms of the Effects of Prunella vulgaris against Subacute Thyroiditis Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1158740
Modern Language Association (MLA)
Shen, Xin…[et al.]. Analysis of the Molecular Mechanisms of the Effects of Prunella vulgaris against Subacute Thyroiditis Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1158740
American Medical Association (AMA)
Shen, Xin& Yang, Rui& An, Jianpeng& Zhong, Xia. Analysis of the Molecular Mechanisms of the Effects of Prunella vulgaris against Subacute Thyroiditis Based on Network Pharmacology. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1158740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158740