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Orlistat-Induced Gut Microbiota Modification in Obese Mice
Joint Authors
Zhao, Dong
Ke, Jing
An, Yaxin
Cao, Bin
Lang, Jianan
Wu, Nannan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Accumulating evidence has indicated that alterations of gut microbiota have been involved in various metabolic diseases.
Orlistat, a reversible inhibitor of pancreatic and gastric lipase, has beneficial effects on weight loss and metabolism.
However, the effect of orlistat on the composition of gut microbiota remains unclear.
Objective.
We aimed to explore the effect of orlistat on gut microbiota in high-fat diet (HFD) fed C57BL/6J obese mice.
Methods.
C57BL/6J mice were randomly divided into three groups: control (NCD), HFD, and HFD + orlistat (ORL).
Mice in the NCD group were fed chow diet, while the other groups were fed HFD for 6 months, and orlistat was added in the final 3 months in the HFD + ORL group.
After sacrifice, body weight and metabolic parameters were assessed, and the gut microbial composition was analyzed by 16S rRNA gene sequencing.
Results.
Orlistat treatment exerted beneficial effects on body weight, plasma cholesterol, and glucose tolerance.
Meanwhile, orlistat treatment modified the gut microbiota, presenting as reduced total microbial abundance and obvious upregulated bacteria.
Moreover, the upregulated bacteria correlated with several metabolic pathways.
Conclusions.
Orlistat may exert beneficial effects on body weight and glucose tolerance through modifying the composition of gut microbiota.
American Psychological Association (APA)
Ke, Jing& An, Yaxin& Cao, Bin& Lang, Jianan& Wu, Nannan& Zhao, Dong. 2020. Orlistat-Induced Gut Microbiota Modification in Obese Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158758
Modern Language Association (MLA)
Ke, Jing…[et al.]. Orlistat-Induced Gut Microbiota Modification in Obese Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158758
American Medical Association (AMA)
Ke, Jing& An, Yaxin& Cao, Bin& Lang, Jianan& Wu, Nannan& Zhao, Dong. Orlistat-Induced Gut Microbiota Modification in Obese Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158758