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Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress
Joint Authors
Lu, Chuan-li
Li, Xiu-fen
Chen, Rui-rong
Liu, Juan
Chen, Zhe
Cai, Wen-jun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In Southwestern China, the root of Morinda angustifolia Roxb.
has been employed as a folk medicine for treating various types of hepatitis and jaundice.
The purpose of this study was to evaluate the hepatoprotective effects of anthraquinones extract from M.
angustifolia root (AEMA) in carbon tetrachloride- (CCl4-) induced liver injury in mice and identify the main bioactive components.
Results indicated that AEMA pretreatment could significantly, in a dose-dependent manner, attenuate the increased levels of ALT and AST in mice serum induced by CCl4.
At doses of 100 and 200 mg/kg, AEMA exhibited significant suppression of the elevated hepatic levels of malondialdehyde (MDA), as well as marked upregulatory effects on the activities of antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice exposed to CCl4.
However, AEMA treatment had no effect on the antioxidant enzyme catalase (CAT) or the nonenzymatic antioxidant glutathione (GSH).
Furthermore, two anthraquinone constituents were isolated from AEMA and identified as soranjidiol and rubiadin-3-methyl ether.
Soranjidiol exhibited similar protective effects to those of AEMA on liver damage induced by CCl4.
Overall, our research clearly demonstrated the hepatoprotective effects of the AEMA, and anthraquinones, particularly soranjidiol, should be considered as the main hepatoprotective principles of M.
angustifolia.
In addition, the underlying mechanism may be, at least in part, related to its antioxidant properties.
American Psychological Association (APA)
Chen, Rui-rong& Liu, Juan& Chen, Zhe& Cai, Wen-jun& Li, Xiu-fen& Lu, Chuan-li. 2020. Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158781
Modern Language Association (MLA)
Chen, Rui-rong…[et al.]. Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1158781
American Medical Association (AMA)
Chen, Rui-rong& Liu, Juan& Chen, Zhe& Cai, Wen-jun& Li, Xiu-fen& Lu, Chuan-li. Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1158781
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1158781