Nomogram-Based New Recurrence Predicting System in Early-Stage Papillary Thyroid Cancer
Joint Authors
Teng, Lisong
Ding, Yongfeng
Mao, Zhuochao
Ruan, Jiaying
Su, Xingyun
Li, Linrong
Wang, Weibin
Fahey, Thomas J.
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Objectives.
The clinicopathological risk factors to predict recurrence of papillary thyroid cancer (PTC) patients remain controversial.
Methods.
PTC patients treated with thyroidectomy between January 1997 and December 2011 at the First Affiliated Hospital of Zhejiang University (Zhejiang cohort) were included.
Multivariate Cox regression analysis was conducted to identify independent recurrence predictors.
Then, the nomogram model for predicting probability of recurrence was built.
Results.
According to Zhejiang cohort (N = 1,697), we found that the 10-year event-free survival (EFS) rates of PTC patients with early-stage (TNM stages I, II, and III) were not well discriminated (91.6%, 89.0%, and 90.7%; P=0.768).
The multivariate Cox model identified age, bilaterality, tumor size, and nodal status as independent risk factors for tumor recurrence in PTC patients with TNM stages I–III.
We then developed a nomogram with the C-index 0.70 (95% CI, 0.64 to 0.76), which was significantly higher (P<0.0001) than the AJCC staging system (0.52).
In the validation group, the C-index remained at a similar level.
Conclusions.
In this study, we build up a new recurrence predicting system and establish a nomogram for early-stage PTC patients.
This prognostic model may better predict individualized outcomes and conduct personalized treatments.
American Psychological Association (APA)
Ding, Yongfeng& Mao, Zhuochao& Ruan, Jiaying& Su, Xingyun& Li, Linrong& Fahey, Thomas J.…[et al.]. 2019. Nomogram-Based New Recurrence Predicting System in Early-Stage Papillary Thyroid Cancer. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1159293
Modern Language Association (MLA)
Ding, Yongfeng…[et al.]. Nomogram-Based New Recurrence Predicting System in Early-Stage Papillary Thyroid Cancer. International Journal of Endocrinology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1159293
American Medical Association (AMA)
Ding, Yongfeng& Mao, Zhuochao& Ruan, Jiaying& Su, Xingyun& Li, Linrong& Fahey, Thomas J.…[et al.]. Nomogram-Based New Recurrence Predicting System in Early-Stage Papillary Thyroid Cancer. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1159293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159293