Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway
Joint Authors
Yu, Xin-Yang
Ma, Xue-Fei
Lin, Wen-Jian
Hao, Ming
Kuang, Hong-Yu
Shao, Ning
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
This study is aimed at investigating whether exenatide (Exe) delays the progression of nonalcoholic fatty liver disease (NAFLD) in C57BL/6 mice by targeting the NLRP3 inflammasome through the autophagy/mitophagy pathway.
Methods.
Thirty male C57BL/6 mice were randomly divided into three groups: control group (n=10), model group (n=10), and Exe (exenatide) group (n=10).
Mouse models of NAFLD and diabetes were established using a high-fat diet and streptozocin.
Results.
The levels of fasting blood glucose (FBG), total cholesterol (TC), and triglyceride (TG) in the serum were significantly reduced after Exe treatment.
The body weight, liver weight/body weight, and number of lipid droplets in the liver significantly decreased in Exe-treated mice.
Treatment with Exe markedly reduced the levels of liver lipids, malondialdehyde (MDA), and alanine aminotransferase (ALT) in serum and livers.
The number of autophagosomes increased significantly in the Exe group.
The expression of LC3A/B-II/I, Beclin-1, Parkin, and BNIP3L increased significantly, whereas NLRP3 and IL-1β proteins were suppressed after Exe treatment.
Conclusion.
We successfully established a mouse model of NAFLD and diabetes.
Exe may reduce oxidative stress injury and inhibit the NLRP3 inflammasome by enhancing the autophagy/mitophagy pathway in liver, which has a protective effect on the liver in NAFLD and diabetes in C57BL/6 mice.
American Psychological Association (APA)
Shao, Ning& Yu, Xin-Yang& Ma, Xue-Fei& Lin, Wen-Jian& Hao, Ming& Kuang, Hong-Yu. 2018. Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1159308
Modern Language Association (MLA)
Shao, Ning…[et al.]. Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway. Gastroenterology Research and Practice No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1159308
American Medical Association (AMA)
Shao, Ning& Yu, Xin-Yang& Ma, Xue-Fei& Lin, Wen-Jian& Hao, Ming& Kuang, Hong-Yu. Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1159308
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159308