Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells
Joint Authors
Zhou, Jiali
Kang, Xincong
Luo, Yushuang
Yuan, Yuju
Wu, Yanyang
Wang, Meijun
Liu, Dongbo
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetes is a metabolic disease, partly due to hypoinsulinism, which affects ∼8% of the world’s adult population.
Glibenclamide is known to promote insulin secretion by targeting β cells.
Autophagy as a self-protective mechanism of cells has been widely studied and has particular physiological effects in different tissues or cells.
However, the interaction between autophagy and glibenclamide is unclear.
In this study, we investigated the role of autophagy in glibenclamide-induced insulin secretion in pancreatic β cells.
Herein, we showed that glibenclamide promoted insulin release and further activated autophagy through the adenosine 5′-monophosphate (AMP) activated protein kinase (AMPK) pathway in MIN-6 cells.
Inhibition of autophagy with autophagy inhibitor 3-methyladenine (3-MA) potentiated the secretory function of glibenclamide further.
These results suggest that glibenclamide-induced autophagy plays an inhibitory role in promoting insulin secretion by activating the AMPK pathway instead of altering the mammalian target of rapamycin (mTOR).
American Psychological Association (APA)
Zhou, Jiali& Kang, Xincong& Luo, Yushuang& Yuan, Yuju& Wu, Yanyang& Wang, Meijun…[et al.]. 2019. Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1159318
Modern Language Association (MLA)
Zhou, Jiali…[et al.]. Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells. International Journal of Endocrinology No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1159318
American Medical Association (AMA)
Zhou, Jiali& Kang, Xincong& Luo, Yushuang& Yuan, Yuju& Wu, Yanyang& Wang, Meijun…[et al.]. Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1159318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159318