Water Carcinogenicity and Prevalence of HPV Infection in Esophageal Cancer Patients in Huaihe River Basin, China
Joint Authors
Ghaffar, Maliha
Li, Jintao
Zhang, Lei
Khodahemmati, Sara
Wang, Minglian
Wang, Yangjunqi
Zhao, Lijiao
Jia, Runqing
Chen, Su
Zeng, Yi
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
The incidence of the upper gastrointestinal tumor has increased rapidly during recent decades.
The relationship between local water pollution and the tumor is still not much clear, so this study was conducted to further investigate the local water pollution and its influence on the malignant cell transformation.
Prevalence of human papillomavirus (HPV) in local esophageal cancer (EC) patients was also analyzed in Shenqiu County for the first time.
Methods.
Two-step cell transformation was used to study different sources of water in the malignant cell transformation, and the existence of 3-methylcholanthrene (3-MC) in water was analyzed from the river and shallow and deep wells.
HPV DNA in tissue samples of EC patients was detected by polymerase chain reaction (PCR) and HPV diagnostic kit.
Results.
The river water has higher cytotoxicity than the shallow well water and induced significant cell malignant transformation, while deep well water has not shown the malignant cell transformation.
In Huaihe River water, the 3-MC concentration was found higher than shallow and deep wells.
An HPV infection rate was found high in patients with esophageal cancer.
Conclusion.
Long-term consumption of polluted water can induce malignant cell transformation, and the presence of HPV may be an important cause of cancer.
American Psychological Association (APA)
Ghaffar, Maliha& Li, Jintao& Zhang, Lei& Khodahemmati, Sara& Wang, Minglian& Wang, Yangjunqi…[et al.]. 2018. Water Carcinogenicity and Prevalence of HPV Infection in Esophageal Cancer Patients in Huaihe River Basin, China. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1159341
Modern Language Association (MLA)
Ghaffar, Maliha…[et al.]. Water Carcinogenicity and Prevalence of HPV Infection in Esophageal Cancer Patients in Huaihe River Basin, China. Gastroenterology Research and Practice No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1159341
American Medical Association (AMA)
Ghaffar, Maliha& Li, Jintao& Zhang, Lei& Khodahemmati, Sara& Wang, Minglian& Wang, Yangjunqi…[et al.]. Water Carcinogenicity and Prevalence of HPV Infection in Esophageal Cancer Patients in Huaihe River Basin, China. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1159341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159341