Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1AMPK Signaling Pathway
Joint Authors
Yu, Peng
Xu, Xi
Zhang, Jing
Xia, Xuan
Xu, Fen
Weng, Jianping
Lai, Xiaoyang
Shen, Yunfeng
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide (LR) had been experimentally and clinically shown to ameliorate nonalcoholic fatty liver disease (NAFLD).
This study aimed to investigate the beneficial effect of LR on NAFLD in vivo and in vitro and its underlying molecular mechanism.
The effects of LR were examined on the high-fat diet-induced in vivo model in mice and in vitro model of NAFLD in human HepG2 cells.
Liver tissues and HepG2 cells were procured for measuring lipid metabolism, histological examination, and western blot analysis.
LR administration significantly lowered the serum lipid profile and lipid disposition in vitro and in vivo because of the altered expression of enzymes on hepatic gluconeogenesis and lipid metabolism.
Moreover, LR significantly decreased Src homology region 2 domain-containing phosphatase-1 (SHP1) and then increased the expression of phosphorylated-AMP-activated protein kinase (p-AMPK).
However, the overexpression of SHP1 mediated by lentivirus vector reversed LR-induced improvement in lipid deposition.
Moreover, SHP1 silencing could further increase the expression of p-AMPK to ameliorate lipid metabolism and relative lipogenic gene induced by LR.
In addition, abrogation of AMPK by Compound C eliminated the protective effects of LR on lipid metabolism without changing the expression of SHP1.
LR markedly prevented NAFLD through adjusting lipid metabolism via SHP1/AMPK signaling pathway.
American Psychological Association (APA)
Yu, Peng& Xu, Xi& Zhang, Jing& Xia, Xuan& Xu, Fen& Weng, Jianping…[et al.]. 2019. Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1AMPK Signaling Pathway. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159345
Modern Language Association (MLA)
Yu, Peng…[et al.]. Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1AMPK Signaling Pathway. International Journal of Endocrinology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1159345
American Medical Association (AMA)
Yu, Peng& Xu, Xi& Zhang, Jing& Xia, Xuan& Xu, Fen& Weng, Jianping…[et al.]. Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1AMPK Signaling Pathway. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1159345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159345