Surgical Management of Gastric Gastrointestinal Stromal Tumours: Comparison of Outcomes for Local and Radical Resection
Joint Authors
Donohoe, Claire L.
Madhavan, Anantha
Phillips, Alexander W.
Willows, Rebecca J.
Immanuel, Arul
Verril, Mark
Griffin, S. Michael
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Gastrointestinal stromal tumours (GISTs) most commonly originate from the stomach.
Their treatment is dependent on size and whether they are symptomatic.
Curative treatment requires surgery, which may be preceded by neoadjuvant imatinib if it is felt that this will aid in achieving clear (R0) resection margins.
The aim of this study was to evaluate outcomes from patients that underwent a “local” organ-preserving operation, with those that required a more radical resection, and the influences on selecting a more radical resection.
A retrospective review of patients undergoing surgery for symptomatic gastric GISTs from a single institution over 9 years was carried out.
Patients were divided into three cohorts dependent on whether they had a “local” resection, “anatomical” resection, or “extended” resection.
71 patients were included.
Overall, 5-year survival was 92%.
Operating time, blood loss, and length of stay were significantly lower in the group undergoing local resection (p<0.05).
Tumour size was also smaller in the local group (median 4 cm versus 5 cm p<0.05).
Tumour location also influenced the type of surgery performed, with tumours at the cardia, gastroesophageal junction, and antrum all having “anatomical” resections.
Lymphadenectomy did not appear to impact on outcomes.
These findings indicate that local excision, where possible, does not impair oncological outcomes.
American Psychological Association (APA)
Madhavan, Anantha& Phillips, Alexander W.& Donohoe, Claire L.& Willows, Rebecca J.& Immanuel, Arul& Verril, Mark…[et al.]. 2018. Surgical Management of Gastric Gastrointestinal Stromal Tumours: Comparison of Outcomes for Local and Radical Resection. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159363
Modern Language Association (MLA)
Madhavan, Anantha…[et al.]. Surgical Management of Gastric Gastrointestinal Stromal Tumours: Comparison of Outcomes for Local and Radical Resection. Gastroenterology Research and Practice No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1159363
American Medical Association (AMA)
Madhavan, Anantha& Phillips, Alexander W.& Donohoe, Claire L.& Willows, Rebecca J.& Immanuel, Arul& Verril, Mark…[et al.]. Surgical Management of Gastric Gastrointestinal Stromal Tumours: Comparison of Outcomes for Local and Radical Resection. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1159363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159363