Dietary Genistein Could Modulate Hypothalamic Circadian Entrainment, Reduce Body Weight, and Improve Glucose and Lipid Metabolism in Female Mice
Joint Authors
Li, Ming
Zhang, Qian
Xiao, Xinhua
Zhou, Liyuan
Zheng, Jia
Wang, Xiaojing
Deng, Mingqun
Zhai, Xiao
Li, Rongrong
Liu, Jieying
Yu, Miao
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Genistein has beneficial effects on metabolic disorders.
However, the specific mechanism is not clearly understood.
In light of the significant role of the hypothalamus in energy and metabolic homeostasis, this study was designed to explore whether dietary genistein intake could mitigate the harmful effects of a high-fat diet on glucose and lipid metabolism and whether any alterations caused by dietary genistein were associated with hypothalamic gene expression profiles.
C57BL/6 female mice were fed a high-fat diet without genistein (HF), a high-fat diet with genistein (HFG), or a normal control diet (CON) for 8 weeks.
Body weight and energy intake were assessed.
At the end of the study, glucose tolerance and serum levels of insulin and lipids were analyzed.
Hypothalamic tissue was collected for whole transcriptome sequencing and reverse transcription quantitative PCR (RT-qPCR) validation.
Energy intake and body weight were significantly reduced in the mice of the HFG group compared with those of the HF group.
Mice fed the HFG diet had improved glucose tolerance and decreased serum triacylglycerol, free fatty acids, and low-density lipoprotein cholesterol compared with those fed the HF diet.
The HFG diet also modulated gene expression in the hypothalamus; the most abundant genes were enriched in the circadian entrainment pathway.
Dietary genistein intake could reduce body weight, improve glucose and lipid metabolism, and regulate hypothalamic circadian entrainment.
The ability of genistein intake to influence regulation of the hypothalamic circadian rhythm is important since this could provide a novel target for the treatment of obesity and diabetes.
American Psychological Association (APA)
Zhou, Liyuan& Xiao, Xinhua& Zhang, Qian& Zheng, Jia& Li, Ming& Yu, Miao…[et al.]. 2019. Dietary Genistein Could Modulate Hypothalamic Circadian Entrainment, Reduce Body Weight, and Improve Glucose and Lipid Metabolism in Female Mice. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1159368
Modern Language Association (MLA)
Zhou, Liyuan…[et al.]. Dietary Genistein Could Modulate Hypothalamic Circadian Entrainment, Reduce Body Weight, and Improve Glucose and Lipid Metabolism in Female Mice. International Journal of Endocrinology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1159368
American Medical Association (AMA)
Zhou, Liyuan& Xiao, Xinhua& Zhang, Qian& Zheng, Jia& Li, Ming& Yu, Miao…[et al.]. Dietary Genistein Could Modulate Hypothalamic Circadian Entrainment, Reduce Body Weight, and Improve Glucose and Lipid Metabolism in Female Mice. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1159368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159368