Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives
Joint Authors
Pellino, Gianluca
Capasso, Raffaella
Selvaggi, Francesco
Brunese, Luca
Reginelli, Alfonso
Qiu, Shengyang
Kontovounisios, Christos
Gallo, Gaetano
Pallante, Pierlorenzo
Maretto, Isacco
Nikolaou, Stella
Barina, Andrea
Clerico, Giuseppe
Giuliani, Antonio
Sciaudone, Guido
Trompetto, Mario
Malapelle, Umberto
De Stefano, Alfonso
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-13
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide.
It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes.
One out of five patients is diagnosed with metastatic CRC.
The stage of diagnosis influences treatment outcome and survival.
Notwithstanding the recent advances in multidisciplinary management and treatment of CRC, patients are still reluctant to undergo screening tests because of the associated invasiveness and discomfort (e.g., colonoscopy with biopsies).
Moreover, the serological markers currently used for diagnosis are not reliable and, even if they were useful to detect disease recurrence after treatment, they are not always detected in patients with CRC (e.g., CEA).
Recently, translational research in CRC has produced a wide spectrum of potential biomarkers that could be useful for diagnosis, treatment, and follow-up of these patients.
The aim of this review is to provide an overview of the newer noninvasive or minimally invasive biomarkers of CRC.
Here, we discuss imaging and biomolecular diagnostics ranging from their potential usefulness to obtain early and less-invasive diagnosis to their potential implementation in the development of a bespoke treatment of CRC.
American Psychological Association (APA)
Pellino, Gianluca& Gallo, Gaetano& Pallante, Pierlorenzo& Capasso, Raffaella& De Stefano, Alfonso& Maretto, Isacco…[et al.]. 2018. Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1159384
Modern Language Association (MLA)
Pellino, Gianluca…[et al.]. Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives. Gastroenterology Research and Practice No. 2018 (2018), pp.1-21.
https://search.emarefa.net/detail/BIM-1159384
American Medical Association (AMA)
Pellino, Gianluca& Gallo, Gaetano& Pallante, Pierlorenzo& Capasso, Raffaella& De Stefano, Alfonso& Maretto, Isacco…[et al.]. Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1159384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159384