EI24 Suppresses Tumorigenesis in Pancreatic Cancer via Regulating c-Myc
Joint Authors
Qian, Yuting
Wang, Qi
Wei, Lumin
Wang, Lifu
Li, Juanjuan
Xie, Mingping
Zang, Yi
Zhu, Lei
Li, Tong
Tang, Wen-Hao
Liu, Xu
Zhu, Ying
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The EI24 autophagy-associated transmembrane protein is frequently associated with tumor growth and patient survival.
In the present study, we found that EI24 was downregulated in pancreatic ductal adenocarcinoma (PDAC) tissues compared with adjacent normal tissues and was associated with cancer cell differentiation.
Overexpression of EI24 suppressed cancer cell growth in vitro and in vivo and induced cell cycle S phase arrest, with no impact on caspase-dependent apoptosis.
EI24 overexpression also resulted in reduced c-Myc expression, an oncogene in PDAC, accompanied with increased LC3B-II formation, increased Beclin-1, and diminished p62.
Together, we propose that EI24 suppresses cell proliferation and prompts cell cycle arrest in pancreatic cancer cells by activating the autophagic lysosomal degradation of c-Myc.
Our results suggest a potential mechanism underlying the antitumor effects of EI24 in PDAC and provide insight into the crosstalk between autophagy and cell proliferation involving a possible EI24/Beclin-1/p62/c-Myc signaling pathway.
American Psychological Association (APA)
Zang, Yi& Zhu, Lei& Li, Tong& Wang, Qi& Li, Juanjuan& Qian, Yuting…[et al.]. 2018. EI24 Suppresses Tumorigenesis in Pancreatic Cancer via Regulating c-Myc. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1159402
Modern Language Association (MLA)
Zang, Yi…[et al.]. EI24 Suppresses Tumorigenesis in Pancreatic Cancer via Regulating c-Myc. Gastroenterology Research and Practice No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1159402
American Medical Association (AMA)
Zang, Yi& Zhu, Lei& Li, Tong& Wang, Qi& Li, Juanjuan& Qian, Yuting…[et al.]. EI24 Suppresses Tumorigenesis in Pancreatic Cancer via Regulating c-Myc. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1159402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159402