The Association of Nil Per Os (NPO) Days with Necrotizing Enterocolitis
Joint Authors
Guo, Chunbao
Wang, Yongming
Li, Xiaoyu
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Enteral feeds are an essential part of care for infants and may be a potential risk factor in NEC development.
The present study objective was to evaluate the relationship between nil per os (NPO) and clinical outcomes in infants with NEC.
Methods.
This was a retrospective review of 196 premature, low-birth-weight infants with NEC from January 1, 2011, to October 31, 2016, at four academic tertiary care hospitals.
The patients were evaluated based on the median nil per os (NPO) days (5.6 days) in longer NPO (6.3 ± 1.1 days) versus shorter NPO groups (4.2 ± 0.9 days).
Results.
Patients who experienced longer than 5.6 NPO days were more likely associated with perforated NEC (odds ratio (OR), 2.01; 95% confidence interval (CI), 1.07–3.76; p=0.021), stage III NEC (OR, 1.81; 95% CI, 0.97–3.38; p=0.042), and longer duration of mechanical ventilation (OR, 0.17; 95% CI, 0.08–0.98; p=0.005) than the shorter duration group of 5.6 NPO days.
For the secondary outcomes, there was a trend towards earlier birth (p=0.083), longer NICU length of stay (p=0.093), and higher mortality (p=0.10) in the longer NPO cohort (p=0.057).
The incidence of bacterial sepsis and short bowel syndrome also increased as the length of NPO increased.
There was no statistically significant difference in nutritional variables between the two groups within the in-hospital period.
Conclusion.
Longer NPO time was associated with the severity of NEC and more injurious clinical outcomes, as demonstrated by rates of surgical intervention and duration of mechanical ventilation.
American Psychological Association (APA)
Wang, Yongming& Li, Xiaoyu& Guo, Chunbao. 2018. The Association of Nil Per Os (NPO) Days with Necrotizing Enterocolitis. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159411
Modern Language Association (MLA)
Wang, Yongming…[et al.]. The Association of Nil Per Os (NPO) Days with Necrotizing Enterocolitis. Gastroenterology Research and Practice No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1159411
American Medical Association (AMA)
Wang, Yongming& Li, Xiaoyu& Guo, Chunbao. The Association of Nil Per Os (NPO) Days with Necrotizing Enterocolitis. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1159411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159411