Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPKNF-κB Pathway Activity
Joint Authors
Li, Jingjing
Xu, Ling
Li, Sainan
Wang, Chengfen
Lu, Xiya
Wang, Wenwen
Mo, Wenhui
Xia, Yujing
Chen, Kan
Guo, Chuan-Yong
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
Fucosterol is derived from the brown alga Eisenia bicyclis and has various biological activities, including antioxidant, anticancer, and antidiabetic properties.
The aim of this study was to investigate the protective effects of fucosterol pretreatment on Concanavalin A- (ConA-) induced acute liver injury in mice, and to understand its molecular mechanisms.
Materials and Methods.
Acute liver injury was induced in BALB/c mice by ConA (25 mg/kg), and fucosterol (dissolved in 2% DMSO) was orally administered daily at doses of 25, 50, and 100 mg/kg.
The levels of hepatic necrosis, apoptosis, and autophagy associated with inflammatory cytokines were measured at 2, 8, and 24 h.
Results.
Fucosterol attenuated serum liver enzyme levels and hepatic necrosis and apoptosis induced by TNF-α, IL-6, and IL-1β.
Fucosterol also inhibited apoptosis and autophagy by upregulating Bcl-2, which decreased levels of functional Bax and Beclin-1.
Furthermore, reduced P38 MAPK and NF-κB signaling were accompanied by PPARγ activation.
Conclusion.
This study showed that fucosterol could alleviate acute liver injury induced by ConA by inhibiting P38 MAPK/PPARγ/NF-κB signaling.
These findings highlight that fucosterol is a promising potential therapeutic agent for acute liver injury.
American Psychological Association (APA)
Mo, Wenhui& Wang, Chengfen& Li, Jingjing& Chen, Kan& Xia, Yujing& Li, Sainan…[et al.]. 2018. Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPKNF-κB Pathway Activity. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1159420
Modern Language Association (MLA)
Mo, Wenhui…[et al.]. Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPKNF-κB Pathway Activity. Gastroenterology Research and Practice No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1159420
American Medical Association (AMA)
Mo, Wenhui& Wang, Chengfen& Li, Jingjing& Chen, Kan& Xia, Yujing& Li, Sainan…[et al.]. Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPKNF-κB Pathway Activity. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1159420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159420