BRAF V600E Status and Stimulated Thyroglobulin at Ablation Time Increase Prognostic Value of American Thyroid Association Classification Systems for Persistent Disease in Differentiated Thyroid Carcinoma
Joint Authors
Tallini, Giovanni
de Biase, Dario
Repaci, Andrea
Vicennati, Valentina
Paccapelo, Alexandro
Cavicchi, Ottavio
Salituro, Nicola
Monari, Fabio
Altimari, Annalisa
Gruppioni, Elisa
Fiorentino, Michelangelo
Pagotto, Uberto
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Stimulated thyroglobulin levels measured at the time of remnant ablation (A-hTg) and BRAFV600E mutation had shown prognostic value in predicting persistent disease in differentiated thyroid cancer (DTC).
The aim of this study was to evaluate the prognostic role of A-hTg combined with the BRAFV600E status in association with the revised American Thyroid Association (ATA) risk stratification.
Material and Methods.
620 patients treated for a DTC were included in this study with a median follow-up duration of 6.1 years.
All patients underwent total thyroidectomy followed by radioiodine ablation.
Patients with positive anti-thyroglobulin antibodies were excluded.
The predictive value of A-hTg was calculated by receiver operating characteristic curve (ROC curve) analysis.
The Cox proportional hazard regression model, including the BRAF status, A-hTg, and ATA classification system, was assessed to evaluate the existing persistent disease risk.
Results.
Taken together, the BRAF status and A-hTg levels improve the ATA risk classification in all categories.
In particular, in the low-risk ATA classification, only the combination of BRAFV600E+A-hTg>8.9ng/ml was associated with persistent disease (P=0.001, HR 60.2, CI 95% 5.28-687).
In the intermediate-risk ATA classification, BRAFWT+A-hTg>8.9ng/ml was associated with persistent disease (P=0.029, HR 2.71, CI 95% 1.106-6.670) and BRAFV600E+A-hTg>8.9ng/ml was also associated with persistent disease (P<0.001, HR 5.001, CI 95% 2.318-10.790).
In the high-risk ATA classification, both BRAFV600E+A-hTg<8.9ng/ml and BRAFV600E+A-hTg>8.9 ng/ml were associated with persistent disease (P=0.042, HR 5.963, CI 95% 1.069-33.255 and P=0.002, HR 11.564, CI 95% 2.543-52.576, respectively).
Conclusions.
The BRAF status and stimulated thyroglobulin levels at ablation time improve the ATA risk stratification of differentiated thyroid cancer; therefore, even A-hTg could be included in risk classification factors.
American Psychological Association (APA)
Repaci, Andrea& Vicennati, Valentina& Paccapelo, Alexandro& Cavicchi, Ottavio& Salituro, Nicola& Monari, Fabio…[et al.]. 2019. BRAF V600E Status and Stimulated Thyroglobulin at Ablation Time Increase Prognostic Value of American Thyroid Association Classification Systems for Persistent Disease in Differentiated Thyroid Carcinoma. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1159449
Modern Language Association (MLA)
Repaci, Andrea…[et al.]. BRAF V600E Status and Stimulated Thyroglobulin at Ablation Time Increase Prognostic Value of American Thyroid Association Classification Systems for Persistent Disease in Differentiated Thyroid Carcinoma. International Journal of Endocrinology No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1159449
American Medical Association (AMA)
Repaci, Andrea& Vicennati, Valentina& Paccapelo, Alexandro& Cavicchi, Ottavio& Salituro, Nicola& Monari, Fabio…[et al.]. BRAF V600E Status and Stimulated Thyroglobulin at Ablation Time Increase Prognostic Value of American Thyroid Association Classification Systems for Persistent Disease in Differentiated Thyroid Carcinoma. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1159449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159449