Correlation of Oncotype DX Recurrence Score with Histomorphology and Immunohistochemistry in over 500 Patients
Joint Authors
Bleiweiss, Ira
Hanna, Matthew G.
Nayak, Anupma
Jaffer, Shabnam
Source
International Journal of Breast Cancer
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Oncotype Dx is used to determine the recurrence risk (RR) in patients with estrogen receptor positive (ER+) and lymph node negative (LN−) breast cancer.
The RR is divided into low (0–17), intermediate (18–30), and high (31) to predict chemotherapy benefit.
Our goal was to determine the association between histomorphology, immunohistochemistry, and RR.
We retrospectively identified 536 patients with ER+ and LN− breast cancers that underwent Oncotype testing from 2006 to 2013.
Tumor size ranged from 0.2 cm to 6.5 cm (mean = 1.3 cm) and was uniform in all 3 categories.
The carcinomas were as follows: ductal = 63.2%, lobular = 11.1%, and mixed = 35.7%.
The RR correlated with the Nottingham grade.
Increasing RR was inversely related to PR positivity but directly to Her2 positivity.
Of the morphologic parameters, a tubular(lobular) morphology correlated only with low-intermediate scores and anaplastic type with intermediate-high scores.
Other morphologies like micropapillary and mucinous were uniformly distributed in each category.
Carcinomas with comedo intraductal carcinoma were more likely associated with high RR.
Forty-four patients with either isolated tumor cells or micrometastases were evenly distributed amongst the 3 RR.
While there was only 1 ER discrepancy between our immunohistochemistry (3+ 80%) and Oncotype, up to 8% of PR+ cases (mean = 15%, median = 5%) and 2% of HER2+ cases were undervalued by Oncotype.
American Psychological Association (APA)
Hanna, Matthew G.& Bleiweiss, Ira& Nayak, Anupma& Jaffer, Shabnam. 2017. Correlation of Oncotype DX Recurrence Score with Histomorphology and Immunohistochemistry in over 500 Patients. International Journal of Breast Cancer،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1159528
Modern Language Association (MLA)
Hanna, Matthew G.…[et al.]. Correlation of Oncotype DX Recurrence Score with Histomorphology and Immunohistochemistry in over 500 Patients. International Journal of Breast Cancer No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1159528
American Medical Association (AMA)
Hanna, Matthew G.& Bleiweiss, Ira& Nayak, Anupma& Jaffer, Shabnam. Correlation of Oncotype DX Recurrence Score with Histomorphology and Immunohistochemistry in over 500 Patients. International Journal of Breast Cancer. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1159528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159528