The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Zhang, Xiaoshuai
Zheng, Yang
Guo, Yanan
Lai, Zhiwen
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objective.
To assess the effect of a low carbohydrate diet (LCD) on women with polycystic ovary syndrome (PCOS).
Methods.
Data from randomized controlled trials (RCTs) were obtained to perform a meta-analysis of the effects of LCD in PCOS patients.
The primary outcomes included the changes in BMI, homeostatic model assessment for insulin resistance (HOMA-IR), and blood lipids, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), follicle-stimulating hormone (FSH), luteotropic hormone (LH), total testosterone (T), and sex hormone-binding globulin (SHBG).
Results.
Eight RCTs involving 327 patients were included.
In comparison with the control group, the LCD decreased BMI (SMD = −1.04, 95% CI (−1.38, −0.70), P<0.00001), HOMA-IR (SMD = −0.66, 95% CI (−1.01, −0.30), P<0.05), TC (SMD = −0.68, 95% CI (−1.35, −0.02), P<0.05), and LDL-C (SMD = −0.66, 95% CI (−1.30, −0.02), P<0.05).
Stratified analyses indicated that LCD lasting longer than 4 weeks had a stronger effect on increasing FSH levels (MD = 0.39, 95% CI (0.08, 0.71), P<0.05), increasing SHBG levels (MD = 5.98, 95% CI (3.51, 8.46), P<0.05), and decreasing T levels (SMD = −1.79, 95% CI (−3.22, −0.36), P<0.05), and the low-fat and low-CHO LCD (fat <35% and CHO <45%) had a more significant effect on the levels of FSH (MD = 0.40, 95% CI (0.09, 0.71), P<0.05) and SHBG (MD = 6.20, 95% CI (3.68, 8.72), P<0.05) than the high-fat and low-CHO LCD (fat >35% and CHO <45%).
Conclusion.
Based on the current evidence, LCD, particularly long-term LCD and low-fat/low-CHO LCD, may be recommended for the reduction of BMI, treatment of PCOS with insulin resistance, prevention of high LDL-C, increasing the levels of FSH and SHBG, and decreasing the level of T level.
Together, the analyzed data indicate that proper control of carbohydrate intake provides beneficial effects on some aspects of PCOS and may represent one of the important interventions improving the clinical symptoms of affected patients.
American Psychological Association (APA)
Zhang, Xiaoshuai& Zheng, Yang& Guo, Yanan& Lai, Zhiwen. 2019. The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1159532
Modern Language Association (MLA)
Zhang, Xiaoshuai…[et al.]. The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1159532
American Medical Association (AMA)
Zhang, Xiaoshuai& Zheng, Yang& Guo, Yanan& Lai, Zhiwen. The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1159532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159532