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Polymorphisms in Adipokines in Mexican Children with Obesity
Joint Authors
Granados, Julio
Jiménez-Osorio, Angélica Saraí
Rodríguez-Arellano, Martha Eunice
Aguilar-Lucio, Alma Olivia
Cárdenas-Hernández, Helios
Musalem-Younes, Claudette
Solares-Tlapechco, Jacqueline
Costa-Urrutia, Paula
Medina-Contreras, Oscar
Source
International Journal of Endocrinology
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The high prevalence of childhood obesity in Mexico is alarming in the health-science field.
We propose to investigate the contribution of adipokines and cytokines polymorphisms and common BMI/obesity-associated loci, revealed in genome-wide association studies in Caucasian adult cohorts, with childhood obesity.
This study included 773 Mexican-Mestizo children (5-15 years old) in a case-control study.
The polymorphisms included were ADIPOQ (rs6444174), TNF-α (rs1800750), IL-1β (rs1143643), IL-6 (rs1524107; rs2069845), NEGR1 (rs34305371), SEC16B-RASAL2 (rs10913469), TMEM18 (rs6548238; rs7561317), GNPDA2 (rs16857402), LEP (rs2167270), MTCH2 (rs10838738), LGR4-LIN7C-BDNF (rs925946), BCDIN3D-FAIM2 (rs7138803), FTO (rs62033400), MC4R (rs11872992), MC4R (rs17782313), and KCTD15 (rs29942).
No significant contribution was found with adipokines and cytokines polymorphisms in this study.
Only both TMEM18 (rs6548238; rs7561317) polymorphisms were found associated with obesity (OR=0.5, P=0.008) and were in linkage disequilibrium (r2=0.87).
The linear regression showed that the rs7561317 polymorphism of TMEM18 is negatively associated with obesity.
This report highlights the influence of TMEM18 in Mexican-Mestizo children obesity, while adipokine and cytokine polymorphisms were not associated with it.
American Psychological Association (APA)
Jiménez-Osorio, Angélica Saraí& Aguilar-Lucio, Alma Olivia& Cárdenas-Hernández, Helios& Musalem-Younes, Claudette& Solares-Tlapechco, Jacqueline& Costa-Urrutia, Paula…[et al.]. 2019. Polymorphisms in Adipokines in Mexican Children with Obesity. International Journal of Endocrinology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1159548
Modern Language Association (MLA)
Jiménez-Osorio, Angélica Saraí…[et al.]. Polymorphisms in Adipokines in Mexican Children with Obesity. International Journal of Endocrinology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1159548
American Medical Association (AMA)
Jiménez-Osorio, Angélica Saraí& Aguilar-Lucio, Alma Olivia& Cárdenas-Hernández, Helios& Musalem-Younes, Claudette& Solares-Tlapechco, Jacqueline& Costa-Urrutia, Paula…[et al.]. Polymorphisms in Adipokines in Mexican Children with Obesity. International Journal of Endocrinology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1159548
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159548