Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study
Joint Authors
Asaoka, Daisuke
Yao, Takashi
Matsumoto, Kohei
Akazawa, Yoichi
Nakagawa, Yuta
Takeda, Tsutomu
Komori, Hiroyuki
Izumi, Kentaro
Shimada, Yuji
Ueyama, Hiroya
Hojo, Mariko
Nagahara, Akihito
Matsumoto, Kenshi
Watanabe, Sumio
Source
Gastroenterology Research and Practice
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Endoscopic submucosal dissection (ESD) of esophageal tumors can cause stenosis, yet the effect of esophageal ESD on motility remains unclarified.
This study aimed to compare esophageal motility and symptoms, before and after ESD, using high-resolution manometry (HRM) and symptom scoring.
Methods.
Twenty-eight patients with 35 cT1a cancers were prospectively enrolled between December 2014 and February 2016.
Pre- and post-ESD symptom score and HRM were recorded.
Based on circumferential resection (CR), patients were divided into group A (n=17, <2/3 CR) or B (n=11, 2/3 CR or greater).
HRM parameters evaluated were distal contractile integral (DCI), contractile front velocity (CFV), intrabolus pressure, integrated relaxation pressure, distal latency, and peristaltic breaks.
Results.
Symptom scores worsened after ESD in 8/11 patients in group B, and 0/17 patients in group A.
There was no significant difference in any HRM parameter after ESD in the whole study group but mean DCI tended to increase (p=0.07).
In group B, DCI increased significantly after ESD (p=0.04), and CFV tended to decrease after ESD (p=0.08).
Conclusions.
DCI tended to increase after esophageal ESD.
ESD affected the symptom score and esophageal motility in cases with 2/3 CR or greater.
This trial is registered with UMIN000015829.
American Psychological Association (APA)
Takeda, Tsutomu& Matsumoto, Kenshi& Nagahara, Akihito& Komori, Hiroyuki& Akazawa, Yoichi& Nakagawa, Yuta…[et al.]. 2018. Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study. Gastroenterology Research and Practice،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1159551
Modern Language Association (MLA)
Takeda, Tsutomu…[et al.]. Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study. Gastroenterology Research and Practice No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1159551
American Medical Association (AMA)
Takeda, Tsutomu& Matsumoto, Kenshi& Nagahara, Akihito& Komori, Hiroyuki& Akazawa, Yoichi& Nakagawa, Yuta…[et al.]. Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study. Gastroenterology Research and Practice. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1159551
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159551