P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site
Joint Authors
Tafe, Laura J.
Marotti, Jonathan D.
Muller, Kristen E.
Demidenko, Eugene
Miller, Todd W.
Source
International Journal of Breast Cancer
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-Rex1) has been implicated in cancer growth, metastasis, and response to phosphatidylinositol 3-kinase (PI3K) inhibitor therapy.
The aim of this study was to determine whether P-Rex1 expression differs between primary and metastatic human breast tumors and between breast cancer subtypes.
Design.
P-Rex1 expression was measured in 133 specimens by immunohistochemistry: 40 and 42 primary breast tumors from patients who did versus did not develop metastasis, respectively, and 51 breast-derived tumors from metastatic sites (36 of which had matching primary tumors available for analysis).
Results.
Primary breast tumors showed significant differences in P-Rex1 expression based on receptor subtype.
ER+ and HER2+ primary tumors showed higher P-Rex1 expression than primary triple-negative tumors.
HER2+ metastases from all sites showed significantly higher P-Rex1 expression compared to other metastatic receptor subtypes.
Solid organ (i.e., brain, lung, and liver) metastases showed higher P-Rex1 expression compared to bone metastases.
Conclusions.
P-Rex1 expression is increased in ER+ and HER2+ breast cancers compared to triple-negative tumors.
P-Rex1 may be differentially expressed in metastatic tumors based on site and receptor status.
The role of P-Rex1 in the development of breast cancer metastases and as a predictive biomarker of therapeutic response warrants further investigation.
American Psychological Association (APA)
Marotti, Jonathan D.& Muller, Kristen E.& Tafe, Laura J.& Demidenko, Eugene& Miller, Todd W.. 2017. P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site. International Journal of Breast Cancer،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1159563
Modern Language Association (MLA)
Marotti, Jonathan D.…[et al.]. P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site. International Journal of Breast Cancer No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1159563
American Medical Association (AMA)
Marotti, Jonathan D.& Muller, Kristen E.& Tafe, Laura J.& Demidenko, Eugene& Miller, Todd W.. P-Rex1 Expression in Invasive Breast Cancer in relation to Receptor Status and Distant Metastatic Site. International Journal of Breast Cancer. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1159563
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1159563